Cummings David E, Schwartz Michael W
Department of Medicine, VA Puget Sound Health Care System and Harborview Medical Center, University of Washington, Seattle, Washington 98195, USA.
Annu Rev Med. 2003;54:453-71. doi: 10.1146/annurev.med.54.101601.152403. Epub 2001 Dec 3.
Obesity has become a leading public health concern. Over 1 billion people are now overweight or obese, and the prevalence of these conditions is rising rapidly. Remarkable new insights into the mechanisms that control body weight are providing an increasingly detailed framework for a better understanding of obesity pathogenesis. Key peripheral signals, such as leptin, insulin, and ghrelin, have been linked to hypothalamic neuropeptide systems, and the anatomic and functional networks that integrate these systems have begun to be elucidated. This article highlights some of these recent findings and their implications for the future of obesity treatment.
肥胖已成为主要的公共卫生问题。目前，超过10亿人超重或肥胖，且这些情况的患病率正在迅速上升。对控制体重机制的显著新见解为更好地理解肥胖发病机制提供了日益详细的框架。关键的外周信号，如瘦素、胰岛素和胃饥饿素，已与下丘脑神经肽系统相关联，整合这些系统的解剖和功能网络也已开始得到阐明。本文重点介绍了一些近期的研究发现及其对肥胖治疗未来的影响。
