通过吡咯-咪唑聚酰胺对1型人类免疫缺陷病毒长末端重复序列进行靶向去抑制。
Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides.
作者信息
Coull Jason J, He Guocheng, Melander Christian, Rucker Victor C, Dervan Peter B, Margolis David M
机构信息
Division of Infectious Diseases, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.
出版信息
J Virol. 2002 Dec;76(23):12349-54. doi: 10.1128/jvi.76.23.12349-12354.2002.
Abstract
The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in vitro and within cells via direct access to chromatin, resulting in increased LTR expression.
摘要
宿主因子LSF通过介导组蛋白去乙酰化酶的募集来抑制1型人类免疫缺陷病毒（HIV-1）的长末端重复序列（LTR）。我们发现，靶向LTR的吡咯-咪唑聚酰胺能够通过直接作用于染色质，在体外和细胞内特异性地阻断LSF的结合，从而导致LTR表达增加。
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