通过吡咯-咪唑聚酰胺对1型人类免疫缺陷病毒长末端重复序列进行靶向去抑制。
Targeted derepression of the human immunodeficiency virus type 1 long terminal repeat by pyrrole-imidazole polyamides.
作者信息
Coull Jason J, He Guocheng, Melander Christian, Rucker Victor C, Dervan Peter B, Margolis David M
机构信息
Division of Infectious Diseases, Department of Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.
出版信息
J Virol. 2002 Dec;76(23):12349-54. doi: 10.1128/jvi.76.23.12349-12354.2002.
Abstract
The host factor LSF represses the human immunodeficiency virus type 1 long terminal repeat (LTR) by mediating recruitment of histone deacetylase. We show that pyrrole-imidazole polyamides targeted to the LTR can specifically block LSF binding both in vitro and within cells via direct access to chromatin, resulting in increased LTR expression.
摘要
宿主因子LSF通过介导组蛋白去乙酰化酶的募集来抑制1型人类免疫缺陷病毒（HIV-1）的长末端重复序列（LTR）。我们发现，靶向LTR的吡咯-咪唑聚酰胺能够通过直接作用于染色质，在体外和细胞内特异性地阻断LSF的结合，从而导致LTR表达增加。
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本文引用的文献
1
Counterregulation of chromatin deacetylation and histone deacetylase occupancy at the integrated promoter of human immunodeficiency virus type 1 (HIV-1) by the HIV-1 repressor YY1 and HIV-1 activator Tat.
Mol Cell Biol. 2002 May;22(9):2965-73. doi: 10.1128/MCB.22.9.2965-2973.2002.
2
The human factors YY1 and LSF repress the human immunodeficiency virus type 1 long terminal repeat via recruitment of histone deacetylase 1.
J Virol. 2000 Aug;74(15):6790-9. doi: 10.1128/jvi.74.15.6790-6799.2000.
3
Activation of gene expression by small molecule transcription factors.
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):3930-5. doi: 10.1073/pnas.97.8.3930.
4
Anti-repression of RNA polymerase II transcription by pyrrole-imidazole polyamides.
Biochemistry. 1999 Aug 17;38(33):10801-7. doi: 10.1021/bi9912847.
5
Inhibition of Ets-1 DNA binding and ternary complex formation between Ets-1, NF-kappaB, and DNA by a designed DNA-binding ligand.
J Biol Chem. 1999 Apr 30;274(18):12765-73. doi: 10.1074/jbc.274.18.12765.
6
Inhibition of major-groove-binding proteins by pyrrole-imidazole polyamides with an Arg-Pro-Arg positive patch.
Chem Biol. 1998 Mar;5(3):119-33. doi: 10.1016/s1074-5521(98)90057-6.
7
Histone acetyltransferases regulate HIV-1 enhancer activity in vitro.
Genes Dev. 1997 Dec 15;11(24):3327-40. doi: 10.1101/gad.11.24.3327.
8
Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF.
J Virol. 1997 Dec;71(12):9375-82. doi: 10.1128/JVI.71.12.9375-9382.1997.
9
Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy.
Science. 1997 Nov 14;278(5341):1295-300. doi: 10.1126/science.278.5341.1295.
10
Recovery of replication-competent HIV despite prolonged suppression of plasma viremia.
Science. 1997 Nov 14;278(5341):1291-5. doi: 10.1126/science.278.5341.1291.
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