Ortolan Erika, Vacca Paola, Capobianco Andrea, Armando Enrico, Crivellin Federico, Horenstein Alberto, Malavasi Fabio
Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino Medical School, Via Santena 19, 10126 Turin, Italy.
Cell Biochem Funct. 2002 Dec;20(4):309-22. doi: 10.1002/cbf.978.
CD157 is a pleiotropic ectoenzyme which belongs to the CD38 family and to the growing number of leukocyte surface molecules known to act independently as both receptors and enzymes. A 45-kDa surface structure with a GPI anchor, the CD157 molecule displays two distinct domains in its extracellular component. The first is implicated in the enzymic activities of the molecule and the second features adhesion/signalling properties. CD157 shares several characteristics with CD38, including a similar amino acid sequence and enzymic functions. Both molecules are involved in the metabolism of NAD(+), and the CD157 gene is synthenic on 4p15 with CD38, with which it also shares a unique genomic organization. Their conservation in phylogeny is striking evidence for their relevance in the life and death cycle of the cell.
CD157是一种多效性胞外酶，属于CD38家族，并且是越来越多已知可独立作为受体和酶发挥作用的白细胞表面分子之一。CD157分子是一种具有糖基磷脂酰肌醇（GPI）锚定的45 kDa表面结构，在其细胞外成分中显示出两个不同的结构域。第一个结构域与该分子的酶活性有关，第二个结构域具有粘附/信号传导特性。CD157与CD38具有若干共同特征，包括相似的氨基酸序列和酶功能。这两种分子都参与NAD(+)的代谢，并且CD157基因在4p15上与CD38同线，它们还共享独特的基因组组织。它们在系统发育中的保守性是其在细胞生死循环中相关性的显著证据。
