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Alterations in the expression of insulin-like growth factors and their binding proteins in lung cancer.

作者信息

Coleman Carrie M, Grimberg Adda

机构信息

Division of Endocrinology and Diabetes, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

出版信息

Methods Mol Med. 2003;74:167-86. doi: 10.1385/1-59259-323-2:167.

DOI:10.1385/1-59259-323-2:167
PMID:12415693
Abstract
摘要

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1
Alterations in the expression of insulin-like growth factors and their binding proteins in lung cancer.肺癌中胰岛素样生长因子及其结合蛋白表达的改变。
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3
Role for membrane and secreted insulin-like growth factor-binding protein-2 in the regulation of insulin-like growth factor action in lung tumors.膜结合型和分泌型胰岛素样生长因子结合蛋白-2在肺癌中胰岛素样生长因子作用调控中的作用
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Insulin-like growth factors stimulate the release of insulin-like growth factor-binding protein-3 (IGFBP-3) and degradation of IGFBP-4 in nonsmall cell lung cancer cell lines.胰岛素样生长因子可刺激非小细胞肺癌细胞系中胰岛素样生长因子结合蛋白-3（IGFBP-3）的释放及胰岛素样生长因子结合蛋白-4（IGFBP-4）的降解。
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Ontogenic changes in the circulating concentrations of insulin-like growth factor (IGF)-I, IGF-II, and IGF-binding proteins in the chicken embryo.
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Insulin-like growth factor binding protein-3 is a new predictor of radiosensitivity on esophageal squamous cell carcinoma.胰岛素样生长因子结合蛋白-3 是预测食管鳞癌放射敏感性的新标志物。
Sci Rep. 2015 Dec 16;5:17336. doi: 10.1038/srep17336.
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The overexpression of IGFBP-3 is involved in the chemosensitivity of esophageal squamous cell carcinoma cells to nimotuzumab combined with cisplatin.IGFBP - 3的过表达与食管鳞状细胞癌细胞对尼妥珠单抗联合顺铂的化疗敏感性有关。
Tumour Biol. 2012 Aug;33(4):1115-23. doi: 10.1007/s13277-012-0352-0. Epub 2012 Mar 3.
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Insulin-like growth factor factor binding protein-2 is a novel mediator of p53 inhibition of insulin-like growth factor signaling.
胰岛素样生长因子结合蛋白-2是p53抑制胰岛素样生长因子信号传导的一种新型介质。
Cancer Biol Ther. 2006 Oct;5(10):1408-14. doi: 10.4161/cbt.5.10.3455. Epub 2006 Oct 30.
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Cancer.癌症。
Adv Exp Med Biol. 2005;567:305-39. doi: 10.1007/0-387-26274-1_13.
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p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia.脱氧核糖核酸损伤和缺氧对胰岛素样生长因子结合蛋白-3的p53依赖性和非p53依赖性诱导作用
J Clin Endocrinol Metab. 2005 Jun;90(6):3568-74. doi: 10.1210/jc.2004-1213. Epub 2005 Mar 15.
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Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3.表皮生长因子受体调节胰岛素样生长因子结合蛋白3的异常表达。
Cancer Res. 2004 Nov 1;64(21):7711-23. doi: 10.1158/0008-5472.CAN-04-0715.