[端粒酶：一种在癌症研究中有多种应用的酶]

[Telomerase: an enzyme with multiple applications in cancer research].

作者信息

Castillo Ureta Hipólito, Barrera Saldaña Hugo A, Martínez Rodríguez Herminia G

机构信息

Laboratorio de Biología Celular, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, N.L., México.

出版信息

Rev Invest Clin. 2002 Jul-Aug;54(4):342-8.

PMID:12415959

Abstract

The telomerase is a ribonucleoprotein enzyme to which multiple functions have been attributed, the most important of these is the maintenance of the telomere which is related with cellular immortalization and cancer. 85% of human tumors have telomerase activity, that in normal cells goes undetected. These characteristics make the telomerase an attractive target for chemotherapy.

摘要

端粒酶是一种核糖核蛋白酶，具有多种功能，其中最重要的是维持端粒，这与细胞永生化和癌症相关。85%的人类肿瘤具有端粒酶活性，而在正常细胞中则检测不到。这些特性使端粒酶成为化疗的一个有吸引力的靶点。