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免疫功能正常者患隐球菌肺炎后继发隐球菌性脑膜炎

[Cryptococcal meningitis following cryptococcal pneumonia in an immunocompetent].

作者信息

Reichman N, Elias M, Raz R, Flatau E

机构信息

Dept. of Internal Medicine B, Infectious Disease Unit, HaEmek Hospital, Afula.

出版信息

Harefuah. 1999 Oct;137(7-8):291-2, 350.

Abstract

Cryptococcal meningitis (CM) is common in the immunocompromised (especially due to AIDS), but also occurs in immunocompetent subjects. CM can complicate cryptococcal pneumonia (CP) not only in the immunocompromised but also in the immunocompetent. We describe a healthy 26-year-old man who developed a prolonged lung infection. Diagnosis of cryptococcal pneumonia was established from bronchoscopic washings. He recovered spontaneously, so no antifungal treatment was given. 4 months later he was admitted with cryptococcal meningitis and was treated successfully with amphotericin B. An extensive immunologic study revealed no abnormalities. Since CM can complicate cryptococcal pneumonia, it is recommended that patients with CP be followed, even if recovery is apparently complete.

摘要

隐球菌性脑膜炎(CM)在免疫功能低下者中常见(尤其是因艾滋病导致),但也见于免疫功能正常者。CM不仅可使免疫功能低下者的隐球菌性肺炎(CP)复杂化,也可使免疫功能正常者的隐球菌性肺炎复杂化。我们描述了一名26岁的健康男性,他发生了持续时间较长的肺部感染。通过支气管灌洗确诊为隐球菌性肺炎。他自行康复,因此未给予抗真菌治疗。4个月后,他因隐球菌性脑膜炎入院,接受两性霉素B治疗并成功治愈。广泛的免疫学检查未发现异常。由于CM可使隐球菌性肺炎复杂化,因此建议对CP患者进行随访,即使表面上已完全康复。

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