McMillan Donald C, Forrest Lynn M, O'Gorman Patricia, Angerson Wilson J, McArdle Colin S
University Department of Surgery, Royal Infirmary, Glasgow G31 2ER, UK.
Nutr Cancer. 2002;42(2):191-3. doi: 10.1207/S15327914NC422_7.
In the advanced cancer patient, performance status has considerable prognostic power. Karnofsky performance status, together with variables reported to influence its score, was measured in advanced gastrointestinal cancer patients (n = 148). For male and female patients, age, body mass index, weight loss, triceps skinfold thickness, mid-upper arm circumference, albumin, C-reactive protein, and tumor type and stage were regressed against Karnofsky performance status. On multiple regression analysis, only mid-upper arm circumference and log10 C-reactive protein in men (r2 = 0.462, P < 0.0001) and only mid-upper arm circumference and weight loss in women (r2 = 0.485, P < 0.01) were independent predictors of Karnofsky performance status. There was a significant partial correlation, with gender as a covariable, between log10 C-reactive protein and albumin (r = -0.530, P < 0.0001) and mid-upper arm circumference (r = -0.269, P = 0.035) and weight loss (r = 0.286, P = 0.024). The results of the present study indicate that mid-upper arm circumference is a major factor that influences performance status in male and female patients with advanced gastrointestinal cancer.
在晚期癌症患者中，体能状态具有相当大的预后预测能力。对晚期胃肠道癌患者（n = 148）测量了卡氏体能状态及其影响评分的相关变量。针对男性和女性患者，将年龄、体重指数、体重减轻、三头肌皮褶厚度、上臂中部周长、白蛋白、C反应蛋白以及肿瘤类型和分期与卡氏体能状态进行回归分析。在多元回归分析中，男性中仅上臂中部周长和log10 C反应蛋白（r2 = 0.462，P < 0.0001），女性中仅上臂中部周长和体重减轻（r2 = 0.485，P < 0.01）是卡氏体能状态的独立预测因素。以性别作为协变量时，log10 C反应蛋白与白蛋白（r = -0.530，P < 0.0001）、上臂中部周长（r = -0.269，P = 0.035）以及体重减轻（r = 0.286，P = 0.024）之间存在显著的偏相关性。本研究结果表明，上臂中部周长是影响晚期胃肠道癌男性和女性患者体能状态的主要因素。
