Department of Oral and Maxillofacial Surgery, Nagoya Ekisaikai Hospital, Nagoya, Japan.
Medicine (Baltimore). 2022 Mar 18;101(11). doi: 10.1097/MD.0000000000029094.
Systemic inflammatory responses and nutritional status are useful prognostic factors in gastric cancer patients. Since oral hypofunction causes undernutrition, we cross-sectionally investigated whether nutritional biomarkers were affected by the occlusal supporting zone status.In 114 gastric cancer patients, the gastric cancer stage, body mass index, albumin levels, total lymphocyte counts, cholesterol levels, C-reactive protein levels, and 4 nutritional biomarkers - the Glasgow prognostic score (GPS), neutrophil-lymphocyte ratio, prognostic nutrition index (PNI), and controlling nutritional status (CONUT) - were evaluated. Oral conditions were assessed by determining the number of remaining teeth. The occlusal supporting status was based on the Eichner classification. Patients were assigned into 3 groups per their occlusal status, and mean values were compared using the Kruskal-Wallis test. The mean age and body mass index were 72.2 ± 8.5 (50-89) years and 22.0 ± 3.6 (14.8-33.4), respectively. There were 42, 39, 23, and 10 patients in stages I, II, III, and IV, respectively. The mean number of remaining teeth was 18.1 ± 9.5. According to the Eichner classification, there were 45, 42, and 27 patients in groups A, B, and C, respectively. The GPS and neutrophil-lymphocyte ratio values and CONUT frequencies between groups A and C were significantly different (P = .033, P = .00097, P = .04, respectively; Mann-Whitney U test). PNI values were lower in group C with poor occlusal support zones than in group A with stable occlusal support zones.Occlusal supporting zone reductions were undernutrition associated. Eichner Class C patients with few occlusal supporting zones had poor GPS, PNI, and CONUT values and were undernourished.
全身炎症反应和营养状况是胃癌患者有用的预后因素。由于口腔功能低下导致营养不良，我们横截面对营养生物标志物是否受咬合支持区状况的影响进行了研究。在 114 例胃癌患者中，评估了胃癌分期、体重指数、白蛋白水平、总淋巴细胞计数、胆固醇水平、C 反应蛋白水平以及 4 种营养生物标志物 - 格拉斯哥预后评分 (GPS)、中性粒细胞-淋巴细胞比值、预后营养指数 (PNI) 和控制营养状况 (CONUT)。通过确定剩余牙齿的数量来评估口腔状况。咬合支持状况基于 Eichner 分类。根据咬合状况将患者分为 3 组，使用 Kruskal-Wallis 检验比较平均值。平均年龄和体重指数分别为 72.2 ± 8.5（50-89）岁和 22.0 ± 3.6（14.8-33.4）。I、II、III 和 IV 期患者分别为 42、39、23 和 10 例。平均剩余牙齿数为 18.1 ± 9.5。根据 Eichner 分类，A、B 和 C 组分别有 45、42 和 27 例患者。A 组和 C 组的 GPS 和中性粒细胞-淋巴细胞比值值和 CONUT 频率差异有统计学意义（P =.033，P =.00097，P =.04；Mann-Whitney U 检验）。C 组咬合支持区较差的患者 PNI 值低于 A 组咬合支持区稳定的患者。咬合支持区减少与营养不良有关。Eichner 分类 C 组咬合支持区少的患者 GPS、PNI 和 CONUT 值较低，存在营养不良。
