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犬疱疹病毒澳大利亚分离株的糖蛋白基因B、C、D、G、H和I、胸苷激酶和蛋白激酶基因以及基因同源物UL24的核苷酸序列

Nucleotide sequence of glycoprotein genes B, C, D, G, H and I, the thymidine kinase and protein kinase genes and gene homologue UL24 of an Australian isolate of canine herpesvirus.

作者信息

Reubel Gerhard Herbert, Pekin Jenny, Webb-Wagg Kyleen, Hardy Christopher Miles

机构信息

Pest Animal Control Cooperative Research Centre, CSIRO Sustainable Ecosystems, Canberra, Australia.

出版信息

Virus Genes. 2002 Oct;25(2):195-200. doi: 10.1023/a:1020118003743.

Abstract

We report the complete nucleotide (nt) sequence of nine genes of an Australian isolate of canine herpesvirus (CHV). Four of them are located in the unique short (US) region: glycoprotein (g) genes gG, gD and gI, and the protein kinase gene. Five are in the unique long (UL) region: the thymidine kinase gene, gB, gC, gH, and gene homologue UL24. Partial sequence was determined for four genes, two in the UL region (UL21 and virion protein) and two in the US region (US2 and gE). A repeat sequence of 382 nt with unknown function was identified in the 615 nt intergenic region between gH and UL21. A total of 16.93 kb was sequenced and compared with sequences from CHV isolates from the USA, France, Japan and Australia. Only minor nt and/or amino acid (aa) differences were observed.

摘要

我们报告了一株澳大利亚犬疱疹病毒(CHV)分离株九个基因的完整核苷酸(nt)序列。其中四个位于独特短区域(US):糖蛋白(g)基因gG、gD和gI以及蛋白激酶基因。五个位于独特长区域(UL):胸苷激酶基因、gB、gC、gH以及基因同源物UL24。测定了四个基因的部分序列,两个在UL区域(UL21和病毒体蛋白),两个在US区域(US2和gE)。在gH和UL21之间615 nt的基因间隔区域中鉴定出一个功能未知的382 nt重复序列。总共测序了16.93 kb,并与来自美国、法国、日本和澳大利亚的CHV分离株序列进行了比较。仅观察到微小的核苷酸和/或氨基酸差异。

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