Advanced Technology Development Center, Kyoritsu Seiyaku Corporation, Tsukuba, Ibaraki 300-1252,Japan.
J Clin Microbiol. 2010 Apr;48(4):1176-81. doi: 10.1128/JCM.02128-09. Epub 2010 Jan 27.
Canine herpesvirus (CHV; Canid herpesvirus 1) is principally a perinatal pathogen of pregnant bitches and newborn pups and secondarily a respiratory tract pathogen of older pups and dogs. Infectious disease of the canine respiratory tract frequently occurs among dogs in groups, in which it is called " infectious tracheobronchitis" (ITB). Mortality from ITB is generally negligible, and the clinical importance of CHV as an ITB pathogen is considered to be low. The present report describes a novel ITB outbreak accompanied by death among aged dogs in an animal medical center. Most inpatient dogs had received medications that could induce immunosuppression. CHV was the only pathogen identified, and several CHV isolates were recovered in cell culture. No other viral pathogens or significant bacterial pathogens were found. Molecular and serological analyses revealed that the causative CHV isolates were from a single source but that none was a peculiar strain when the strains were compared with previous CHV strains. The virus had presumably spread among the dogs predisposed to infection in the center. The present results serve as a warning to canine clinics that, under the specific set of circumstances described, such serious CHV outbreaks may be expected wherever canine ITB occurs.
犬疱疹病毒（CHV；犬疱疹病毒 1）主要是怀孕母犬和新生幼犬的围产期病原体，其次是年长幼犬和犬的呼吸道病原体。犬呼吸道传染病在群体中的犬中经常发生，在这种情况下被称为“传染性气管支气管炎”（ITB）。ITB 的死亡率通常可以忽略不计，因此 CHV 作为 ITB 病原体的临床重要性被认为较低。本报告描述了在动物医疗中心，年老犬中发生的一种伴有死亡的新型 ITB 暴发。大多数住院犬都接受了可能引起免疫抑制的药物治疗。CHV 是唯一鉴定出的病原体，并且从细胞培养中回收了几个 CHV 分离株。未发现其他病毒病原体或重要的细菌病原体。分子和血清学分析表明，引起疾病的 CHV 分离株来自单一来源，但与先前的 CHV 分离株相比，没有一个是特殊的菌株。该病毒可能在该中心易感染的犬之间传播。本结果警告犬科诊所，在描述的特定情况下，只要犬发生 ITB，就可能会出现如此严重的 CHV 暴发。
