Vyas Kaushal, Gala Bharat, Sawant Prabha, Das Haribhakti Seba, Kulhalli Prabhakar M, Mahajan Shriram S
Department of Gastroenterology, Lokmanya Tilak Municipal Medical College and Hospital, Mumbai.
Indian J Gastroenterol. 2002 Sep-Oct;21(5):176-8.
Color Doppler is a noninvasive method for assessing portal hemodynamics. Laser Doppler velocimetry is useful in assessment of microcirculatory abnormalities in portal hypertensive gastropathy (PHG).
To study portal hemodynamics by color Doppler and gastric mucosal blood flow (GMBF) by laser Doppler velocimetry in patients with cirrhosis.
Twenty-eight patients with cirrhosis of liver (24 men) and 10 healthy subjects (7 men) were studied. Portal venous blood flow (PVBF) and portal flow velocity (PFV) were assessed by color Doppler at the level where the hepatic artery crosses the portal vein, and GMBF was measured by laser Doppler velocimetry.
PVBF (379.5 [102.9] mL/min), PFV (5.3 [1.1] cm/sec) and GMBF (3.5 [0.8] volts) were significantly lower in patients with cirrhosis than in controls. PVBF and PFV were significantly lower in patients in Child class B and C than those in class A. Patients with ascites had significantly lower PVBF, PFV and GMBF than those without; values were also lower in patients with PHG than in those without. History of bleeding had no relation with PVBF and PFV. GMBF showed good correlation with PVBF (r=0.58, p<0.001) and with PFV (r=0.48, p<0.01).
In cirrhosis of liver, PVBF, PFV and GMBF are significantly lower, and the changes increase with increasing severity of liver disease.
彩色多普勒是一种评估门静脉血流动力学的非侵入性方法。激光多普勒测速仪有助于评估门静脉高压性胃病（PHG）中的微循环异常。
通过彩色多普勒研究肝硬化患者的门静脉血流动力学，并通过激光多普勒测速仪研究胃黏膜血流（GMBF）。
对28例肝硬化患者（24例男性）和10名健康受试者（7例男性）进行研究。在肝动脉与门静脉交叉处，通过彩色多普勒评估门静脉血流（PVBF）和门静脉流速（PFV），并通过激光多普勒测速仪测量GMBF。
肝硬化患者的PVBF（379.5 [102.9] mL/分钟）、PFV（5.3 [1.1] cm/秒）和GMBF（3.5 [0.8] 伏）显著低于对照组。Child B级和C级患者的PVBF和PFV显著低于A级患者。有腹水的患者的PVBF、PFV和GMBF显著低于无腹水者；有PHG的患者的值也低于无PHG者。出血史与PVBF和PFV无关。GMBF与PVBF（r = 0.58，p < 0.001）和PFV（r = 0.48，p < 0.01）显示出良好的相关性。
在肝硬化中，PVBF、PFV和GMBF显著降低，且这些变化随着肝病严重程度的增加而增加。
