Nybakken Kent, Perrimon Norbert
Department of Genetics, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115-6092, USA.
Biochim Biophys Acta. 2002 Dec 19;1573(3):280-91. doi: 10.1016/s0304-4165(02)00395-1.
Heparan sulphate proteoglycans (HSPG's) are cell surface proteins to which long, unbranched chains of modified sugars called heparan sulphate glycosaminoglycans have been covalently attached. Cell culture studies have demonstrated that HSPG's are required for optimal signal transduction by many secreted cell signaling molecules. Now, genetic studies in both Drosophila and vertebrates have illustrated that HSPG's play important roles in signal transduction in vivo and have also begun to reveal new roles for HSPG's in signaling events. In particular, HSPG's have been shown to be important in ligand sequestration of wingless, for the transport of the Hedgehog ligand, and for modulation of the Dpp morphogenetic gradient.
硫酸乙酰肝素蛋白聚糖（HSPG）是一种细胞表面蛋白，其上共价连接着被称为硫酸乙酰肝素糖胺聚糖的长链、无分支的修饰糖。细胞培养研究表明，许多分泌型细胞信号分子进行最佳信号转导需要HSPG。现在，果蝇和脊椎动物的遗传学研究表明，HSPG在体内信号转导中发挥重要作用，并且也开始揭示HSPG在信号事件中的新作用。特别是，已证明HSPG在无翅蛋白的配体隔离、刺猬索尼克蛋白配体的运输以及Dpp形态发生梯度的调节中很重要。
