Perrier A
Clinique de Médecine 1, Département de Médecine, Hôpital Cantonal Universitaire de Genève, Genève, Suisse, France.
Rev Mal Respir. 2002 Sep;19(4):505-14.
This paper, first of a series devoted to evidence-based medicine, describes how to critically read an article on a randomised controlled intervention trial. This guide is applied to the common clinical question, whether or not to prescribe systemic glucocorticoids for patients with exacerbation of chronic obstructive pulmonary disease, through the analysis of two recently published series. It comprises a three-step evaluation: the assessment of the study methods to ensure that the results are valid, the analysis of the results of the larger of the two studies, and the evaluation of whether the results can be applied to a patient whose clinical case illustrates this article. Finally, a few limitations of randomised controlled trials are discussed.
本文是关于循证医学系列文章的第一篇，介绍了如何批判性地阅读一篇关于随机对照干预试验的文章。通过对最近发表的两个系列研究的分析，本指南应用于一个常见的临床问题，即对于慢性阻塞性肺疾病急性加重患者是否开具全身性糖皮质激素。它包括三个步骤的评估：评估研究方法以确保结果有效，分析两项研究中规模较大的那项研究的结果，以及评估这些结果是否可应用于一个临床病例能说明本文内容的患者。最后，讨论了随机对照试验的一些局限性。
