Obtułowicz Krystyna, Kapusta Maria, Antoszczyk Grazyna
Zakład Alergologii Przemysłowej Katedra Medycyny Pracy i Chorób, Srodowiskowych Collegium Medicum, Uniwersytet Jagielloński, Kraków.
Przegl Lek. 2002;59(6):430-2.
The studies were performed in 32 patients in the age range of 17-58 years suffering from bronchial asthma in the exacerbation period of their illness. 16 patients suffered from IgE related/atopic and 16 from IgE non IgE related/nonatopic bronchial asthma. The complement haemolytic activity (CH50) and the activity of C1 inhibitor (C1 INH) were measured in the plasma. In 60% of patients with IgE related asthma and in 45% of patients with non IgE related asthma we stated decrease of CH50. The activity of C1INH also was decreased in 80% of patients with atopic asthma and in 40% of patients with nonatopic asthma. The observed changes were not related to aspirin tolerance as well as to IgE mediation of their illness. Control examinations of these parameters repeated during remission of asthma symptoms in 11 patients with low values during the exacerbation of the illness (in 5 patients with atopic and in 6 with non-atopic asthma) revealed an increase of their values; however without features of normalisation.
这些研究是在32名年龄在17至58岁之间、处于疾病加重期的支气管哮喘患者中进行的。16名患者患有IgE相关/特应性支气管哮喘，16名患有IgE非相关/非特应性支气管哮喘。检测了血浆中的补体溶血活性（CH50）和C1抑制剂（C1 INH）活性。在60%的IgE相关哮喘患者和45%的非IgE相关哮喘患者中，我们发现CH50降低。在80%的特应性哮喘患者和40%的非特应性哮喘患者中，C1INH活性也降低。观察到的变化与阿司匹林耐受性以及疾病的IgE介导无关。对11名在疾病加重期这些参数值较低的患者（5名特应性哮喘患者和6名非特应性哮喘患者）在哮喘症状缓解期间重复进行的这些参数的对照检查显示，其值有所增加；然而，没有恢复正常的特征。
