Dorticós Balea Francisco, Dorantes Sánchez Margarita, Arbaiza Simón Jorge Luis, Castro Hevia Jesús, Zayas Molina Roberto, Quiñones Pérez Miguel Angel, Fayad Rodríguez Yanela
Servicio de Arritmias y Estimulación Cardíaca, Instituto de Cardiología y Cirugía Cardiovascular Ciudad de La Habana, Cuba.
Arch Cardiol Mex. 2002 Jul-Sep;72(3):203-8.
The Brugada syndrome is the most frequent electrical cause of sudden death in patients with structurally normal heart. It is characterized by ST segment elevation in V1-V3 leads, pseudo right bundle branch block and proneness for episodes of life-threatening ventricular cardiac arrhythmias. The aim of this study was to characterize patients with Brugada syndrome identified in Cuba between 1995 and 2001. Fourteen patients with these electrical signs (13 male and 1 female, mean age 42.8) were studied. Seven of them were symptomatic and seven were not. The pharmacological test with sodium channel blockers was very useful (it was positive for all the patients). HV interval was normal. Programmed ventricular stimulation was performed. Ventricular arrhythmia was inducible in 3 symptomatic patients and 2 asymptomatic. All the symptomatic patients and those asymptomatic in whom ventricular arrhythmia was inducible received automatic defibrillators. One clinical recurrence of ventricular arrhythmias was observed. Antiarrhythmic drugs were only used rarely. Clinical history and electrocardiographic tracings were very important to diagnose this syndrome. There were light, transient or masked electrical signs. The treatment of choice is the implantable cardioverter-defibrillator.
Brugada综合征是心脏结构正常患者最常见的导致猝死的电生理原因。其特征为V1-V3导联ST段抬高、假性右束支传导阻滞以及易于发生危及生命的室性心律失常。本研究的目的是对1995年至2001年在古巴确诊的Brugada综合征患者进行特征分析。研究了14例有这些电生理表现的患者（13例男性，1例女性，平均年龄42.8岁）。其中7例有症状，7例无症状。使用钠通道阻滞剂进行的药物试验非常有用（所有患者均为阳性）。HV间期正常。进行了程控心室刺激。3例有症状患者和2例无症状患者可诱发出室性心律失常。所有有症状患者以及可诱发出室性心律失常的无症状患者均接受了植入式除颤器。观察到1例室性心律失常临床复发。抗心律失常药物很少使用。临床病史和心电图记录对诊断该综合征非常重要。存在轻度、短暂或隐匿性电生理表现。治疗的首选方法是植入式心脏复律除颤器。
