Muhonen A, Muhonen J, Lindholm T C, Minn H, Klossner J, Kulmala J, Happonen R P
Department of Oral and Maxillofacial Surgery, University of Turku, Finland.
Int J Oral Maxillofac Surg. 2002 Oct;31(5):519-24. doi: 10.1054/ijom.2002.0257.
The purpose of this study was to analyse the effects of irradiation and hyperbaric oxygenation (HBO) on mandibular osteodistraction (OD). Eighteen rabbits were divided into three groups: 1. Irradiation (R), 2. Irradiation+HBO (R-HO), and 3. Control group (C). Animals of groups R and R-HO received in the mandible irradiation 22.4 Gy in four 5.6 Gy fractions (equivalent to 50 Gy/25 fractions). In addition, group R-HO was given HBO at 2.5 ATA for 90 min per day 18 times preoperatively. Unilateral osteotomy was made 1 month after completion of radiotherapy. After a 1 week latency period bone distraction was started at rate of 1 mm per day, continued for 2 weeks, and left to consolidate for 4 weeks. Amount of new bone was measured histomorphometrically from midsagittal sections. Area of new bone was equal in all groups. Bone was more mature and bone spicules better organized in group C than in groups R and R-HO. Cartilaginous cells were found in distracted bone in all groups but larger chondroid islands were evident only in group R. It seems that despite delayed bone formation, OD can be performed after radiotherapy. HBO had a beneficial effect on bone quality of a previously irradiated mandible.
本研究的目的是分析辐射和高压氧疗（HBO）对下颌骨骨牵引（OD）的影响。18只兔子被分为三组：1. 辐射组（R），2. 辐射+HBO组（R-HO），3. 对照组（C）。R组和R-HO组动物的下颌骨接受22.4 Gy的辐射，分4次，每次5.6 Gy（相当于50 Gy/25次）。此外，R-HO组在术前每天给予2.5 ATA的HBO，每次90分钟，共18次。放疗结束1个月后进行单侧截骨术。经过1周的延迟期后，以每天1毫米的速度开始骨牵引，持续2周，然后让其巩固4周。通过矢状面切片组织形态计量学测量新骨量。所有组的新骨面积相等。与R组和R-HO组相比，C组的骨更成熟，骨小梁组织更好。所有组在牵引的骨中均发现软骨细胞，但仅R组有明显更大的类软骨岛。尽管骨形成延迟，但放疗后似乎仍可进行骨牵引。HBO对先前接受过辐射的下颌骨的骨质有有益影响。
