Morgan Lee Roy, Jursic Branko S, Hooper Catherine L, Neumann Donna M, Thangaraj Kanappan, LeBlanc Blaise
DEKK-TEC, Inc, New Orleans, LA 70119, USA.
Bioorg Med Chem Lett. 2002 Dec 2;12(23):3407-11. doi: 10.1016/s0960-894x(02)00725-4.
The structure of the anticancer agent 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone (A-007) has been modified through SAR and by incorporating barbituric acid, pyridine, quinoline, and alkylcarboxylic acids into A-007's moieties. Analogue anticancer activity and interacting with CD surface markers on a T-cell leukemia cell line were evaluated and the correlation between SAR and biological properties are discussed.
通过构效关系研究以及将巴比妥酸、吡啶、喹啉和烷基羧酸引入抗癌剂4,4'-二羟基二苯甲酮-2,4-二硝基苯腙（A-007）的部分结构中，对其结构进行了修饰。评估了类似物的抗癌活性以及与T细胞白血病细胞系上CD表面标志物的相互作用，并讨论了构效关系与生物学特性之间的相关性。
