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5-硝基噻吩-2-甲醛缩氨基硫脲衍生物的合成及其体外抗寄生虫活性

Synthesis and in vitro antiprotozoal activity of 5-nitrothiophene-2-carboxaldehyde thiosemicarbazone derivatives.

作者信息

Bharti Neelam, Husain Kakul, Gonzalez Garza M T, Cruz-Vega Delia E, Castro-Garza J, Mata-Cardenas Benito D, Naqvi Fehmida, Azam Amir

机构信息

Department of Chemistry, Jamia Millia Islamia, Jamia Nagar, New Delhi, India.

出版信息

Bioorg Med Chem Lett. 2002 Dec 2;12(23):3475-8. doi: 10.1016/s0960-894x(02)00703-5.

DOI:10.1016/s0960-894x(02)00703-5
PMID:12419387
Abstract

Several thiosemicarbazone derivatives of 5-nitrothiophene-2-carboxaldehyde were prepared by the simple process in which N(4)-thiosemicarbazone moiety was replaced by aliphatic, arylic and cyclic amine. Among these thiosemicarbazones compound 11 showed significant antiamoebic activity whereas compound 3 was more active antitrichomonal than the reference drug.

摘要

通过简单的方法制备了几种5-硝基噻吩-2-甲醛的硫代氨基脲衍生物，其中N(4)-硫代氨基脲部分被脂肪族、芳族和环状胺取代。在这些硫代氨基脲中，化合物11表现出显著的抗阿米巴活性，而化合物3的抗滴虫活性比参比药物更强。

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