Kossev Andon R, Schrader Christoph, Däuper Jan, Dengler Reinhard, Rollnik Jens D
Institute of Biophysics, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Neurosci Lett. 2002 Nov 22;333(2):83-6. doi: 10.1016/s0304-3940(02)00986-2.
Using single and paired-pulse transcranial magnetic stimulation we compared the cortical excitability in two different age groups of healthy subjects (mean+/-SD age: 28.5+/-5.2 vs. 56.1+/-4.9 years). Motor evoked potentials were recorded from right extensor and flexor carpi radialis muscles. The effect of paired-pulse stimulation was assessed by the ratio conditioned/unconditioned response area with interstimulus intervals of 3 and 13 ms to test for intracortical inhibition and facilitation, respectively. To test the influence of sensory input the experiments were conducted without and with vibration of the extensor carpi radialis muscle. The intracortical inhibition was significantly greater in older subjects; however, during muscle vibration this difference between the two groups vanished. The different effect of vibration favors compensatory mechanisms to be responsible for a different paired-pulse excitability in middle-aged subjects.
我们使用单脉冲和配对脉冲经颅磁刺激，比较了两个不同年龄组健康受试者的皮质兴奋性（平均±标准差年龄：28.5±5.2岁与56.1±4.9岁）。从右侧桡侧腕伸肌和桡侧腕屈肌记录运动诱发电位。通过条件/非条件反应面积比评估配对脉冲刺激的效果，刺激间隔分别为3毫秒和13毫秒，以分别测试皮质内抑制和易化。为了测试感觉输入的影响，实验分别在不振动和振动桡侧腕伸肌的情况下进行。老年受试者的皮质内抑制明显更强；然而，在肌肉振动期间，两组之间的这种差异消失了。振动的不同影响有利于补偿机制导致中年受试者配对脉冲兴奋性不同。
