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三碘甲状腺原氨酸(T3)、甲状腺甲状旁腺切除术及甲巯咪唑治疗对软骨内骨生长的影响。II. 幼鼠胫骨近端生长器官的生长动力学

Effect of triiodothyronine (T3) thyroparathyroidectomy and mercaptoimidazole treatment on enchondral bone growth. II. Growth dynamics in the proximal growth organ of the tibia in young rats.

作者信息

Lévai G, Petkó M, Varga S, Laczkó J, Gyarmati J

出版信息

Acta Morphol Acad Sci Hung. 1975;23(4):263-70.

PMID:1241967
Abstract

The 24 hour growth rate of the tibial proximal growth organ was investigated in triiodothyronine or mercaptoimidazole-treated, and in thyroidectomized male rats. Longitudinal growth of the tibia of the same period was also studied. After one week treatment, the 24 hour rate of growth in the triiodothyronine-treated rats was retarded as compared with the controls, whereas at the end of the 3rd and 5th weeks the growth rate of the treated animals exceeded that of the controls. The tibia was somewhat longer in the treated rats than in the untreated controls, though the difference was not significant. The growth rate in the growth organ of mercaptoimidazole-treated and thyroidectomized animals was generally higher than that measured in the controls. The length of the tibia was less than in the controls, but the difference was not significant. The phenomenon is attributed to the altered hormonal conditions.

摘要

在经三碘甲状腺原氨酸或巯基咪唑处理以及甲状腺切除的雄性大鼠中,研究了胫骨近端生长器官的24小时生长速率。同时也研究了同一时期胫骨的纵向生长情况。治疗一周后,与对照组相比,经三碘甲状腺原氨酸处理的大鼠的24小时生长速率减缓,而在第3周和第5周结束时,治疗组动物的生长速率超过了对照组。治疗组大鼠的胫骨比未治疗的对照组大鼠略长,尽管差异不显著。巯基咪唑处理组和甲状腺切除组动物生长器官的生长速率总体上高于对照组。胫骨长度小于对照组,但差异不显著。该现象归因于激素条件的改变。

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