Nakagawa Takayuki, Uyama Rina, Ohashi Emi, Takahashi Tomoko, Hong Sung Hyeol, Mochizuki Manabu, Matsunaga Satoru, Nishimura Ryouhei, Sasaki Nobuo
Laboratory of Veterinary Surgery, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan.
J Vet Med Sci. 2002 Oct;64(10):949-52. doi: 10.1292/jvms.64.949.
The expression of sialyl Lewis X (sLe(x)) in 93 canine and 15 feline mammary gland tumors (MGT) obtained by surgical resection at Veterinary Medical Center, the University of Tokyo was examined by immunohistochemistry. Their clinicopathological features and prognosis were also reviewed. Approximately 60% of MGT tissues showed sLe(x) positive expressions, while all normal mammary gland tissues were negative. However, its expression was not correlated with clinicopathological features and prognosis significantly. This study suggests that sLe(x) may be a tumor-associated antigen in canine and feline MGTs.
通过免疫组织化学方法，检测了东京大学兽医学院医学中心通过手术切除获得的93例犬乳腺肿瘤和15例猫乳腺肿瘤（MGT）中唾液酸化路易斯X（sLe(x)）的表达情况。同时回顾了它们的临床病理特征和预后情况。大约60%的MGT组织呈现sLe(x)阳性表达，而所有正常乳腺组织均为阴性。然而，其表达与临床病理特征及预后并无显著相关性。本研究表明，sLe(x)可能是犬猫MGT中的一种肿瘤相关抗原。
