White Raymond P, Offenbacher Steven, Phillips Ceib, Haug Richard H, Blakey George H, Marciani Robert D
Department of Oral and Maxillofacial Surgery, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599-7450, USA.
J Oral Maxillofac Surg. 2002 Nov;60(11):1241-5. doi: 10.1053/joms.2002.35719.
Our goal was to report the detection and levels of gingival crevicular fluid (GCF) inflammatory mediators, sampled at the mesial of 4 first molars and distal of 4 second molars, in 316 patients with asymptomatic third molars.
Levels of GCF inflammatory mediators, interleukin (IL)-1 beta and prostaglandin (PG)E(2), were determined and log transformed for each patient. Z scores were calculated using the mean and standard deviation of the log values for the entire sample of 316 patients. The log mediator levels and Z scores of patients who had probing depths (PDs) less than 5 mm (n = 238) were compared with patients with at least 1 PD equal to or greater than 5 mm (n = 78) on the distal of second molars or around third molars. A periodontal Composite GCF Inflammation Score was calculated for each patient by summing the Z scores obtained for IL-1 beta and PGE(2) for that patient.
The levels of GCF IL-1 beta and PGE(2) were higher if a patient had a PD equal to or greater than 5 mm in the third molar region. The Composite GCF Inflammation Score indicated "elevated inflammation" if a PD equal to or greater than 5 mm was found in the third molar region as well.
These data suggest that asymptomatic patients with PD equal to or greater than 5 mm in the third molar region with associated periodontal attachment loss have increased levels of biochemical mediators of inflammation compared with patients with PD less than 5 mm. These findings are consistent with the concept that early periodontitis in young adults that initiates in the third molar region is associated with increases in key inflammatory mediators.
我们的目标是报告在316例无症状第三磨牙患者中，于4颗第一磨牙近中及4颗第二磨牙远中采集的龈沟液（GCF）炎症介质的检测结果及水平。
测定每位患者GCF炎症介质白细胞介素（IL）-1β和前列腺素（PG）E2的水平，并进行对数转换。使用316例患者整个样本对数值得出的均值和标准差计算Z分数。将第二磨牙远中或第三磨牙周围探诊深度（PD）小于5mm（n = 238）的患者的对数介质水平和Z分数，与至少有1个PD等于或大于5mm（n = 78）的患者进行比较。通过将每位患者IL-1β和PGE2的Z分数相加，计算出每位患者的牙周复合GCF炎症评分。
如果患者第三磨牙区域的PD等于或大于5mm，GCF中IL-1β和PGE2的水平会更高。如果在第三磨牙区域也发现PD等于或大于5mm，复合GCF炎症评分则表明“炎症升高”。
这些数据表明，与PD小于5mm的患者相比，第三磨牙区域PD等于或大于5mm且伴有牙周附着丧失的无症状患者，其炎症生化介质水平升高。这些发现与年轻人中始于第三磨牙区域的早期牙周炎与关键炎症介质增加相关的概念一致。
