Das B K, Arora N K, Mathur P, Ostwal P, Mandal S, Kabra S K, Kapil A, Lalitha M K, Thomas K
Department of Microbiology, All India Institute of Medical Sciences, New Delhi.
Indian J Pediatr. 2002 Sep;69(9):775-7. doi: 10.1007/BF02723690.
Nasopharyngeal colonization of Haemophilus influenzae (H. influenzae) in young children may be important in developing countries.
In this study, we screened school going children for carriage of H. influenzae. A total of 44 H. influenzae isolates out of a collection of 162 were characterized for biotypes, capsular serotypes and antibiotic resistance.
A significant proportion of H. influenzae (25/44) isolates were serotype b. High antibiotic resistance was observed against commonly administered antibiotics like ampicillin (79%), chloramphenicol (20%), trimethoprim sulfamethoxazole (84%) and erythromycin (95%). Comparison of antibiotic resistance profile of nasopharyngeal isolates was observed to be correlated with those of H. influenzae from disease.
Multidrug resistant nasopharyngeal H. influenzae in young healthy children may act as reservoir. Monitoring of antibiotic resistance among nasopharyngeal H. influenzae as a surrogate for invasive H. influenzae seems an attractive option.
在发展中国家，幼儿鼻咽部流感嗜血杆菌（H. influenzae）定植可能具有重要意义。
在本研究中，我们对学龄儿童进行了流感嗜血杆菌携带情况筛查。在162株菌株中，共对44株流感嗜血杆菌分离株进行了生物型、荚膜血清型及抗生素耐药性鉴定。
相当比例（25/44）的流感嗜血杆菌分离株为b型血清型。观察到对常用抗生素如氨苄西林（79%）、氯霉素（20%）、复方新诺明（84%）和红霉素（95%）具有较高的耐药性。观察到鼻咽部分离株的抗生素耐药谱与疾病来源的流感嗜血杆菌的耐药谱相关。
健康幼儿鼻咽部的多重耐药流感嗜血杆菌可能作为储存宿主。监测鼻咽部流感嗜血杆菌的抗生素耐药性作为侵袭性流感嗜血杆菌的替代指标似乎是一个有吸引力的选择。
