Khan I, Zucker-Franklin D, Karpatkin S
Br J Haematol. 1975 Dec;31(4):449-60. doi: 10.1111/j.1365-2141.1975.tb00880.x.
Platelet volume distribution curves were obtained in 20 control subjects and in 21 patients with idiopathic/autoimmune thrombocytopenic purpura. A striking increase in microthrombocytes as well as megathrombocytes was noted in 86% of patients on one or more occasions, particularly in the prsence of severe thrombocytopenia. The entire spectrum of platelet volume distribution curves noted in patients could be reproduced experimentally in rabbits following intravenous injection of anti-platelet antibody. Differential centrifugation studies with control subjects revealed that microthrombocytes were light platelets and megathrombocytes were heavy platelets. Electron microscopy in patients with thrombocytopenia revealed that microthrombocytes were composed of intact small platelets as well as platelet fragments. It is concluded that severe peripheral destruction of platelets is associated with an increase in microthrombocytes as well as megathrombocytes.
在20名对照受试者和21名特发性/自身免疫性血小板减少性紫癜患者中获取了血小板体积分布曲线。在86%的患者中，一次或多次观察到微血小板以及巨血小板显著增加，尤其是在严重血小板减少的情况下。在给兔子静脉注射抗血小板抗体后，患者中观察到的整个血小板体积分布曲线谱可以在实验中重现。对对照受试者进行的差速离心研究表明，微血小板是轻血小板，巨血小板是重血小板。血小板减少患者的电子显微镜检查显示，微血小板由完整的小血小板以及血小板碎片组成。结论是，血小板的严重外周破坏与微血小板以及巨血小板的增加有关。
