胃饥饿素和胰淀素对下丘脑多巴胺、去甲肾上腺素和5-羟色胺释放的影响。
Effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release in the hypothalamus.
作者信息
Brunetti Luigi, Recinella Lucia, Orlando Giustino, Michelotto Barbara, Di Nisio Chiara, Vacca Michele
机构信息
Department of Drug Sciences, G. D'Annunzio University, School of Pharmacy, via dei Vestini, 66013 Chieti, Italy.
出版信息
Eur J Pharmacol. 2002 Nov 15;454(2-3):189-92. doi: 10.1016/s0014-2999(02)02552-9.
Ghrelin and amylin are gut-derived hormones that stimulate and inhibit food intake, respectively. Feeding is modulated by aminergic neurotransmitters in the hypothalamus. We have evaluated the effects of ghrelin and amylin on dopamine, norepinephrine and serotonin release from rat hypothalamic synaptosomes. We found that ghrelin did not modify dopamine or norepinephrine release, but inhibited serotonin release. On the other hand, amylin inhibited dopamine release, without affecting norepinephrine or serotonin. We conclude that the appetite-stimulating activity of ghrelin could be mediated by inhibited serotonin release, while the anorectic effects of amylin could involve inhibited release of dopamine in the hypothalamus.
胃饥饿素和胰淀素是分别刺激和抑制食物摄入的肠道源性激素。进食受下丘脑胺能神经递质调节。我们评估了胃饥饿素和胰淀素对大鼠下丘脑突触体中多巴胺、去甲肾上腺素和5-羟色胺释放的影响。我们发现胃饥饿素不改变多巴胺或去甲肾上腺素的释放，但抑制5-羟色胺的释放。另一方面，胰淀素抑制多巴胺的释放，而不影响去甲肾上腺素或5-羟色胺。我们得出结论，胃饥饿素的促食欲活性可能由5-羟色胺释放受抑制介导，而胰淀素的抑食欲作用可能涉及下丘脑多巴胺释放受抑制。
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