Brunetti Luigi, Orlando Giustino, Ferrante Claudio, Chiavaroli Annalisa, Vacca Michele
Department of Drug Sciences, G. D'Annunzio University, School of Pharmacy, via dei Vestini, 66013 Chieti, Italy.
Eur J Pharmacol. 2005 Sep 5;519(1-2):48-51. doi: 10.1016/j.ejphar.2005.07.008.
Peptide YY (1-36) and peptide YY (3-36) are gut-derived hormones which are involved in feeding control in the hypothalamus. The hypothalamic mechanisms of feeding have been shown to be modulated by aminergic neurotransmitters, which could mediate the anorectic or orexigenic effects of neuropeptides and hormones. We have investigated the role of peptide YY (1-36) and peptide YY (3-36) on dopamine, norepinephrine, and serotonin release from hypothalamic synaptosomes in vitro. We found that peptide YY (3-36) inhibited depolarization-induced dopamine and norepinephrine release, leaving unaffected serotonin release, while peptide YY (1-36) did not modify either basal or stimulated amine release. We can hypothesize that the effects of peptide YY (3-36) could be mediated by inhibited hypothalamic dopamine and norepinephrine release, which could partially account for the anorectic activity of the peptide. On the other hand, peptide YY (1-36), which has a feeding stimulatory role, does not affect aminergic neurotransmission in the hypothalamus.
肽YY（1 - 36）和肽YY（3 - 36）是源自肠道的激素，参与下丘脑的进食控制。进食的下丘脑机制已被证明受胺能神经递质调节，胺能神经递质可介导神经肽和激素的厌食或促食欲作用。我们研究了肽YY（1 - 36）和肽YY（3 - 36）对体外下丘脑突触体中多巴胺、去甲肾上腺素和5-羟色胺释放的作用。我们发现肽YY（3 - 36）抑制去极化诱导的多巴胺和去甲肾上腺素释放，而不影响5-羟色胺释放，而肽YY（1 - 36）既不改变基础胺释放也不改变刺激后的胺释放。我们可以推测，肽YY（3 - 36）的作用可能是通过抑制下丘脑多巴胺和去甲肾上腺素释放介导的，这可能部分解释了该肽的厌食活性。另一方面，具有促进食作用的肽YY（1 - 36）不影响下丘脑的胺能神经传递。
