Bruno Ernesto, Mohamed Ehab I, Alessandrini Marco, Russo Sabino, Schiaroli Stefania, De Lorenzo Antonino, Di Girolamo Alberto
Division of Otorhinolaryngology, Faculty of Medicine and Surgery, University of Rome Tor Vergata, Italy.
Am J Rhinol. 2002 Sep-Oct;16(5):237-41.
The objective of this study was to identify a reproducible clinical parameter for predicting relapses of nasal polyposis after surgery.
Ninety-three patients who had undergone ethmoidectomy of bilateral nasal polyps were followed for 3 years. Nasal polyps were obtained from all patients, and cellular suspensions were analyzed individually using flow cytometry. Based on the percentage of cells in the S phase, we identified three groups of patients (high, medium, and low percentages).
A relapse of nasal polyposis was observed in 15.00, 70.00, and 100.00% of patients from the low-, medium-, and high-percentage groups, respectively. Patients suffering relapses had a high percentage of cells in the S phase.
We identified two cutoff values for the percentage of cells in the S phase; above the first cutoff, some of the patients suffered relapses; above the second cut-off, all patients suffered relapses.
本研究的目的是确定一个可重复的临床参数，用于预测鼻息肉手术后的复发情况。
对93例行双侧鼻息肉筛窦切除术的患者进行了3年的随访。从所有患者中获取鼻息肉，并使用流式细胞术对细胞悬液进行单独分析。根据S期细胞的百分比，我们将患者分为三组（高、中、低百分比）。
低、中、高百分比组患者鼻息肉复发率分别为15.00%、70.00%和100.00%。复发患者的S期细胞百分比很高。
我们确定了S期细胞百分比的两个临界值；高于第一个临界值，部分患者复发；高于第二个临界值，所有患者复发。
