Ruano Gema, Grande Manuel, Anaya Josefa
Departamento de Química Orgánica, Universidad de Salamanca, E-37008 Salamanca, Spain.
J Org Chem. 2002 Nov 15;67(23):8243-6. doi: 10.1021/jo026066p.
The reductive opening of epoxyimonobactams 1 with titanoncene (III) chloride gives rise to radicals that can be trapped by intramolecular pi systems (i.e., conjugated alkenes and lactone and amide carbonyls) in a stereospecific way to give new carbocyclic compounds such as tribactam 2.
环氧单环β-内酰胺1与二氯钛茂（III）发生还原开环反应，生成的自由基可被分子内π体系（即共轭烯烃、内酯和酰胺羰基）以立体专一的方式捕获，从而得到新的碳环化合物，如三β-内酰胺2。
