Ha Zhende, Zhu Yong'an, Zhang Xizhou, Cui Jianhua, Zhang Suping, Ma Yong, Wang Wei, Jian Xinqiong
The 18th Hospital of PLA, Yecheng 844900, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2002 Sep;25(9):527-30.
To study the changes of sleep architecture and blood oxygen saturation (SaO(2)) during sleep in men living at high altitude, and to investigate the effect of rhodiola and acetazolamide on these sleep indexes.
Twenty-four men aged 18 to 21 years who had stayed at high altitude (5 380 m above sea level) for 1 year were randomly divided into groups A (treated with oral rhodiola), B (treated with oral acetazolamide) and C (treated with rhodiola + acetazolamide). Their sleep architecture and SaO(2) were recorded for 24 days before and after taking the medicines.
Compared with baseline, the waking SaO(2) (WSaO(2)), the lowest SaO(2) (LSaO(2)) and the mean SaO(2) (MSaO(2)) were increased significantly after treatment for 24 days (P < 0.01), and the times of oxygen desaturation >/= 4% per hour (DI4) and the percentage of time spent at SaO(2) below 80% (SIT(80)) were decreased significantly (P < 0.01). After treatment, the NREM I and II was shortened, and III + IV and REM sleep were prolonged (P < 0.01): the total waking time (TWT) was shortened, and the sleep efficiency index (SEI) was markedly increased (P < 0.01). Compared with group A's, groups B's and C's SIT(80) were increased (P < 0.05).
Both rhodiola and acetazolamide were effective in modulating the sleep architecture and improving the sleep quality in young men living at high altitude, but there was no synergistic effect between rhodiola and acetazolamide.
研究高海拔地区男性睡眠结构及睡眠期间血氧饱和度（SaO₂）的变化，并探讨红景天和乙酰唑胺对这些睡眠指标的影响。
选取24名年龄在18至21岁、在高海拔（海拔5380米）地区居住1年的男性，随机分为A组（口服红景天治疗）、B组（口服乙酰唑胺治疗）和C组（红景天 + 乙酰唑胺联合治疗）。在服药前后24天记录他们的睡眠结构和SaO₂。
与基线相比，治疗24天后清醒时血氧饱和度（WSaO₂）、最低血氧饱和度（LSaO₂）和平均血氧饱和度（MSaO₂）显著升高（P < 0.01），每小时血氧饱和度下降≥4%的次数（DI4）和血氧饱和度低于80%的时间百分比（SIT₈₀）显著降低（P < 0.01）。治疗后，非快速眼动睡眠I期和II期缩短，III期 + IV期和快速眼动睡眠延长（P < 0.01）：总清醒时间（TWT）缩短，睡眠效率指数（SEI）显著升高（P < 0.01）。与A组相比，B组和C组的SIT₈₀升高（P < 0.05）。
红景天和乙酰唑胺均可有效调节高海拔地区年轻男性的睡眠结构并改善睡眠质量，但红景天和乙酰唑胺之间无协同作用。
