Savoie L L, Lupien P J
Arzneimittelforschung. 1975 Aug;25(8):1284-6.
The acute toxicity of 3-hydroxy-3-methylglutaric acid (HMG) was studied in mice. The LD50 was shown to be 7.33 g/kg p.o. and 3.23 g/kg i.p. Subtoxic and pharmacological doses applied to mice and rats during gestation did not induce malformation of the foetuses and offspring and did not affect the reproductive performances of the dams. This compound is being investigated for its hypolipidemic activity.
研究了3-羟基-3-甲基戊二酸（HMG）对小鼠的急性毒性。经口给药的半数致死量（LD50）为7.33 g/kg，腹腔注射给药的LD50为3.23 g/kg。在妊娠期间对小鼠和大鼠给予亚毒性和药理剂量，未诱导胎儿和后代出现畸形，也未影响母鼠的生殖性能。正在对该化合物的降血脂活性进行研究。
