Khetarpal V K, Sharma P L
Eur J Pharmacol. 1975 Sep-Oct;33(2):325-35. doi: 10.1016/0014-2999(75)90177-6.
The effects of the (+)- and (-)-isomers of propranolol and INPEA on the neuromuscular blocking action of (+)-tubocurarine and succinylcholine were studied in the tibialis anterior-peroneal nerve preparation of the rabbit and the isolated phrenic nerve-diaphragm preparation of the rat. (+)-Tubocurarine-induced neuromuscular blockade was intensified by (+)- and (-)-isomers of INPEA whereas it was unaffected by isomers of propranolol in both preparations. In the rabbit tibialis anterior-peroneal nerve preparation, only the (-)-isomers of propranolol and INPEA increased the duration of succinylcholine-induced neuromuscular blockade without affecting its magnitude. Higher doses of both (+)- and (-)-isomers of propranolol and INPEA potentiated succinylcholine-induced blockade in the rat phrenic nerve-diaphragm preparation. The results obtained indicate that only the increase in duration of succinylcholine-induced blockade with beta-adrenoceptor blockers can be related to beta-blocking property of these compounds.
在兔胫前 - 腓神经标本以及大鼠离体膈神经 - 膈肌标本中，研究了普萘洛尔和吲哌胺的（+） - 异构体及（ - ） - 异构体对（+） - 筒箭毒碱和琥珀酰胆碱神经肌肉阻滞作用的影响。在这两种标本中，吲哌胺的（+） - 异构体及（ - ） - 异构体增强了（+） - 筒箭毒碱引起的神经肌肉阻滞，而普萘洛尔的异构体对此无影响。在兔胫前 - 腓神经标本中，只有普萘洛尔和吲哌胺的（ - ） - 异构体延长了琥珀酰胆碱引起的神经肌肉阻滞的持续时间，而不影响其阻滞强度。在大鼠膈神经 - 膈肌标本中，普萘洛尔和吲哌胺的（+） - 异构体及（ - ） - 异构体的较高剂量均增强了琥珀酰胆碱引起的阻滞。所得结果表明，只有β - 肾上腺素受体阻滞剂延长琥珀酰胆碱引起的阻滞持续时间这一作用可能与这些化合物的β - 阻滞特性有关。
