Carson Michael P, Fisher Allan J, Scorza William E
Department of Medicine, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, New Brunswick, New Jersey 08903, USA.
Obstet Gynecol. 2002 Nov;100(5 Pt 2):1096-7. doi: 10.1016/s0029-7844(02)02106-3.
Terbutaline has direct effects on the cardiac conduction system, but when used to treat preterm labor it is rarely associated with clinically significant cardiac arrhythmias. Commonly used drug references did not list atrial fibrillation as a complication of terbutaline, and our literature search found only one case of atrial fibrillation that occurred with parenteral administration.
A 30-year-old gravida 1 carrying a twin gestation at 35 weeks was taking 2.5 mg oral terbutaline four times daily for premature labor. She developed atrial fibrillation and was ultimately treated by chemical cardioversion with procainamide to restore normal sinus rhythm.
This is the first report of atrial fibrillation during pregnancy associated with oral terbutaline. Atrial fibrillation should be added as a complication of oral terbutaline therapy.
特布他林对心脏传导系统有直接影响，但用于治疗早产时，临床上很少会引发显著的心律失常。常用的药物参考资料未将心房颤动列为特布他林的并发症，而我们的文献检索仅发现1例静脉注射特布他林后出现心房颤动的病例。
一名30岁、孕1产0、孕35周双胎妊娠的孕妇因早产每日口服4次2.5毫克特布他林。她出现了心房颤动，最终通过普鲁卡因胺化学复律恢复了正常窦性心律。
这是孕期口服特布他林相关心房颤动的首例报告。心房颤动应被添加为口服特布他林治疗的并发症。
