拉坦前列素对青光眼患者角膜上皮屏障功能的影响。

Influence of latanoprost on the corneal epithelial barrier function in glaucoma patients.

作者信息

Ishibashi Takeshi, Yokoi Norihiko, Ohtsuki Masanori, Mori Kazuhiko, Komuro Aoi, Kinoshita Shigeru

机构信息

Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Hirokoji-agaru, Kawaramachi-dori, Kamigyo-ku, Kyoto 602-0841, Japan.

出版信息

Ophthalmologica. 2002 Sep-Oct;216(5):351-4. doi: 10.1159/000066180.

DOI:10.1159/000066180

PMID:12424402

Abstract

AIM

To evaluate the influence of topically administered latanoprost, a prostaglandin F(2alpha) analog, on the corneal epithelial barrier function.

PATIENTS AND METHODS

Twenty-four patients suffering from a glaucoma were enrolled. Ten patients without prior topical antiglaucoma medication received topical latanoprost (0.005%, once daily) for 30 days (monotherapy group); 14 patients receiving topical antiglaucoma medication also received latanoprost (0.005%, once daily) for 180 days (combination treatment group). Before and 30 days after treatment (monotherapy group) and before and 30 and 180 days after treatment (combination group), the corneal epithelial barrier function was measured by a fluorophotometric technique.

RESULTS

The fluorescein uptakes in the monotherapy group were 54.6 +/- (SE) 7.5 and 57.1 +/- 11.0 ng/ml before and 30 days after treatment, respectively (p = 0.81). In the combination group, the uptakes were 101.0 +/- 18.3 and 118.9 +/- 25.9 ng/ml (p = 0.38) and 93.4 +/- 17.5 ng/ml (p = 0.58) before and 30 and 180 days after treatment, respectively.

CONCLUSION

The corneal epithelial barrier function remained intact following the instillation of latanoprost in both groups.

摘要

目的

评估局部应用前列腺素F（2α）类似物拉坦前列素对角膜上皮屏障功能的影响。

患者与方法

招募了24例青光眼患者。10例未曾使用过局部抗青光眼药物的患者局部应用拉坦前列素（0.005%，每日1次），持续30天（单药治疗组）；14例正在接受局部抗青光眼药物治疗的患者也应用拉坦前列素（0.005%，每日1次），持续180天（联合治疗组）。在治疗前及治疗后30天（单药治疗组）以及治疗前、治疗后30天和180天（联合治疗组），采用荧光光度技术测量角膜上皮屏障功能。

结果

单药治疗组治疗前及治疗后30天的荧光素摄取量分别为54.6±（标准误）7.5和57.1±11.0 ng/ml（p = 0.81）。联合治疗组治疗前、治疗后30天和180天的摄取量分别为101.0±18.3、118.9±25.9 ng/ml（p = 0.38）和93.4±17.5 ng/ml（p = 0.58）。