Matsuda Nozomu, Matsuura Yutaka, Hoshi Akihiko, Yamanoi Takahiko, Endo Kazuhiro, Honma Mari, Yamamoto Teiji, Sato Sonomi, Kodama Namio
Department of Neurology, Fukushima Medical University.
Rinsho Shinkeigaku. 2002 Feb;42(2):158-61.
A 42-year-old man was admitted due to recurrent bacterial meningitis, as he had been treated here for bacterial meningitis three years prior to the current event. He had a remote history of head injury that he had almost forgotten, and his laboratory data showed no immunodeficiency state. 111In-DTPA cisternography showed an abnormal radioactive accumulation in the frontal lobe adjacent to the left frontal sinus at 23 hours after intrathecal injection, and MPR CT images revealed the left frontal sinus bone fracture. These findings indicated that he had a head injury by which a delayed CSF fistula has been formed. He was surgically treated for a CSF leakage. Although a combination therapy of ABPC and CTRX was efficacious for this patient, this regimen may not be ideal, as meningitis by PRSP has been increasing in incidence. Pneumococcal meningitis, once not a difficult infection to treat, could be a difficult one, as resistant strains to ABPC and CTRX have been more common.
一名42岁男性因复发性细菌性脑膜炎入院,三年前他曾在此接受过细菌性脑膜炎治疗。他有头部受伤史,但时间久远,他几乎都忘记了,实验室检查数据显示他没有免疫缺陷状态。鞘内注射后23小时,铟-111二乙三胺五醋酸脑池造影显示左额窦旁额叶有异常放射性聚集,多平面重建CT图像显示左额窦骨折。这些发现表明他曾头部受伤,导致形成了迟发性脑脊液瘘。他接受了脑脊液漏的手术治疗。虽然阿莫西林/克拉维酸和头孢曲松联合治疗对该患者有效,但由于对青霉素不敏感肺炎链球菌引起的脑膜炎发病率不断上升,该治疗方案可能并不理想。肺炎球菌性脑膜炎,曾经不是一种难以治疗的感染,现在可能变得棘手,因为对阿莫西林/克拉维酸和头孢曲松耐药的菌株越来越常见。