Gonzalez-Angulo Ana M, Orzano Jennifer A, Davila Enrique
Department of Medicine, Mount Sinai Medical Center, Miami Beach, Fla 33140, USA.
South Med J. 2002 Oct;95(10):1215-7.
A 46-year-old man with a history of metastatic transitional cell carcinoma of the bladder received treatment with ifosfamide/mesna. He had reversible encephalopathy after the first cycle of chemotherapy. Adequate clinical response was achieved, with an obvious decrease in tumor size. Subsequently, an identical treatment was given without adverse central nervous system effects. Few data exist about retreatment with intravenous ifosfamide/mesna after induced encephalopathy, but this case suggests that this adverse effect may not recur in some patients.
一名患有转移性膀胱移行细胞癌的46岁男性接受了异环磷酰胺/美司钠治疗。在第一个化疗周期后，他出现了可逆性脑病。取得了充分的临床反应，肿瘤大小明显减小。随后，给予相同的治疗，未出现中枢神经系统不良反应。关于诱导性脑病后静脉注射异环磷酰胺/美司钠再次治疗的数据很少，但该病例表明，这种不良反应在某些患者中可能不会复发。
