吡唑硼酸锌-核碱基配合物，2：（1）Tp（Cum，Me）Zn和Tp（Ph，Me）Zn配合物的制备与结构

Pyrazolylborate-zinc-nucleobase-complexes, 2:(1) preparations and structures of Tp(Cum,Me)Zn and Tp(Ph,Me)Zn complexes.

作者信息

Badura Dirk, Vahrenkamp Heinrich

机构信息

Institut für Anorganische und Analytische Chemie der Universität Freiburg, Albertstr. 21, D-79104 Freiburg, Germany. vahrenka@ uni-freiburg.de

出版信息

Inorg Chem. 2002 Nov 18;41(23):6013-9. doi: 10.1021/ic020280e.

DOI:10.1021/ic020280e

PMID:12425627

Abstract

The interactions of the nine most significant nucleobases (thymine, uracil, dihydrouracil, cytosine, adenine, guanine, diaminopurine, xanthine, hypoxanthine, in their deprotonated forms) with zinc and with themselves in pyrazolylborate zinc complexes Tp(Cum,Me)Zn-base and Tp(Ph,Me)Zn-base are described. Except for guanine, the complexes Tp*Zn-base could be isolated in all cases. Structure determinations could be performed for seven of the eight product types. Except for dihydrouracil and xanthine, the zinc ion is attached to that nitrogen of the base which in nucleosides bears the sugar moiety. In the solid state, all zinc-bound nucleobases are involved in hydrogen bonding interactions. Except for xanthine, this includes homo base pairing across a crystallographic inversion center.

摘要

描述了九种最重要的核碱基（胸腺嘧啶、尿嘧啶、二氢尿嘧啶、胞嘧啶、腺嘌呤、鸟嘌呤、二氨基嘌呤、黄嘌呤、次黄嘌呤，均为去质子化形式）与锌以及它们自身在吡唑硼酸锌配合物Tp(Cum,Me)Zn-碱基和Tp(Ph,Me)Zn-碱基中的相互作用。除了鸟嘌呤外，在所有情况下都可以分离出配合物Tp*Zn-碱基。对于八种产物类型中的七种可以进行结构测定。除了二氢尿嘧啶和黄嘌呤外，锌离子与碱基中在核苷中连接糖部分的那个氮原子相连。在固态中，所有与锌结合的核碱基都参与氢键相互作用。除了黄嘌呤外，这包括通过晶体学反演中心的同碱基配对。