Lu Bingbing, He Quanying, Chen Qing, Huang Xueping, Li Jing
Department of Respiratory Medicine, People's Hospital, Peking University, Beijing 100044, China.
Zhonghua Yi Xue Za Zhi. 2002 Aug 25;82(16):1136-9.
To study whether familial aggregation exists in pulmonary function impairment and COPD.
Pulmonary function, smoking habits, history of occupational dust exposure and clinical manifestation among 117 children of 59 smokers with COPD and 55 children of 28 control smokers without COPD. A multivariate linear regression analysis was carried out to study FEV1 among the children. Logistic regression analysis was conducted to study the factors influencing the FEV1 < 70% pred.
Height and male gender were positively correlated to children's FEV1 (ml); whereas age, clinical symptoms, history of occupational dust exposure and being children of diseased probands were negatively correlated to children's FEV1 (ml). With other relevant factors adjusted, the FEV1 (ml) was lower among those being children of COPD patients; the more severe the COPD conditions of the parents, the lower the FEV1 of the children. Cigarette consumption having clinical symptoms, and being children of COPD probands showed increased risk of FEV1 below 70% predicted (OR = 1.987). Height, age, and history of occupational dust exposure were not correlated to FEV1 < 70% pred among children.
Being children of COPD parents is the independent risk factor for lower FEV1 (ml) and FEV1 below 70% pred, which demonstrates the presence of familial aggregation of COPD and pulmonary function impairment.
研究肺功能损害和慢性阻塞性肺疾病（COPD）是否存在家族聚集性。
对59名患有COPD的吸烟者的117名子女以及28名无COPD的对照吸烟者的55名子女进行肺功能、吸烟习惯、职业性粉尘暴露史和临床表现的调查。采用多元线性回归分析研究儿童的第一秒用力呼气容积（FEV1）。进行逻辑回归分析以研究影响FEV1<预测值70%的因素。
身高和男性性别与儿童的FEV1（毫升）呈正相关；而年龄、临床症状、职业性粉尘暴露史以及患病先证者的子女与儿童的FEV1（毫升）呈负相关。在调整其他相关因素后，COPD患者的子女的FEV1（毫升）较低；父母的COPD病情越严重，子女的FEV1越低。有临床症状、吸烟量以及是COPD先证者的子女，FEV1低于预测值70%的风险增加（比值比=1.987）。身高、年龄和职业性粉尘暴露史与儿童FEV1<预测值70%无关。
COPD患者的子女是FEV1（毫升）降低和FEV1低于预测值70%的独立危险因素，这表明COPD和肺功能损害存在家族聚集性。
