Gao Yan, Di Ping, Peng Xin, Yu Guangyan, Sun Kaihua
Department of Oral Pathology, Peking University School of Stomatology, Beijing 100081, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2002 Sep;37(5):356-8.
To investigate the clinicopathological features of mucinous adenocarcinoma of salivary glands.
The clinical manifestations and histopathological characteristics of 6 cases of mucinous adenocarcinoma of salivary gland were studied by retrospective and routine histopathology and immunohistochemistry.
Four mucinous adenocarcinoma occurred in palate and 2 in mouth floor. Average age of patients was 60 years (48 - 70) and males were affected more often than females (4:2). Pathologically, the tumor grew with infiltration of surrounding tissues. The tumor consisted of unitary mucinous cells and mucin pool was obvious. The cell pleomorphism and nuclear mitosis were often seen. Some tumors showed acinus-like structure. Tumor cells often formed incomplete duct-like structure and small clusters floating in mucinous pool. There were intracellular mucin and signet ring cells in the tumor. Tumor cells showed positive reaction to PAS, Alcin blue, and some cytokeratin staining.
Mucinous adenocarcinoma of salivary gland is a rare malignant tumor which mainly affects palate and mouth floor of older patients. The tumor may originate from acinic cell of mucous acinus or multi-potential cell of salivary gland.
探讨涎腺黏液腺癌的临床病理特征。
回顾性分析6例涎腺黏液腺癌的临床表现及组织病理学特征，采用常规组织病理学及免疫组织化学方法。
4例黏液腺癌发生于腭部，2例发生于口底。患者平均年龄60岁（48 - 70岁），男性多于女性（4:2）。病理上，肿瘤呈浸润性生长，周围组织受侵。肿瘤由单一的黏液细胞构成，黏液池明显，细胞多形性及核分裂常见，部分肿瘤呈腺泡样结构，肿瘤细胞常形成不完全的导管样结构及小细胞团漂浮于黏液池中，肿瘤细胞内可见黏液及印戒细胞。肿瘤细胞对PAS、阿尔辛蓝及部分细胞角蛋白染色呈阳性反应。
涎腺黏液腺癌是一种少见的恶性肿瘤，主要累及老年患者的腭部和口底，肿瘤可能起源于黏液性腺泡的腺泡细胞或涎腺的多潜能细胞。
