Müller A
Arch Gynakol. 1975 Oct 30;218(4):281-93. doi: 10.1007/BF00672330.
By using microanalytic Hydroxyproline (HP)-determination method (Woessner and Stegemann) the content of collagen in 50 normal and pathologicaltered placentae of the second part of pregnancy was measured. A positive linear correlation is demonstrated between HP-concentration and age of pregnancy in normal placentae. Most of the pathologic altered placentae have a lower content of collagen. HP-content measured in main stem and terminal villi of further 35 placentae showed the essential influence of the main stem villi on total placental collagen concentration. In the second part of gestation the HP-concentrations of the main stem villi rise on a factor about 5-6, in the terminal villi they remain constant. The values measured within both groups of villi show a great dispersion. The quantitative results were compared with the histology of the placentae.
采用微量分析羟脯氨酸（HP）测定法（沃斯纳和施特格曼法），对50例妊娠中期正常及病理改变的胎盘组织中的胶原蛋白含量进行了测定。结果表明，正常胎盘组织中HP浓度与妊娠年龄呈正线性相关。大多数病理改变的胎盘组织中胶原蛋白含量较低。对另外35例胎盘的主干绒毛和终末绒毛进行HP含量测定，结果显示主干绒毛对胎盘总胶原蛋白浓度有重要影响。在妊娠中期，主干绒毛的HP浓度升高约5 - 6倍，终末绒毛的HP浓度保持不变。两组绒毛的测定值显示出很大的离散度。将定量结果与胎盘组织学结果进行了比较。
