Burnett Kathryn M, Scott Michael G, Kearney Patricia M, Humphreys W George, McMillen Robert M
Antrim Hospital Academic Pharmacy Practice Unit, Antrim Area Hospital, Bush Road, Antrim, BT41 2RL, UK.
Pharm World Sci. 2002 Oct;24(5):182-7. doi: 10.1023/a:1020565000571.
The aim of this study was to introduce a protocol for the use of antimicrobials in surgical prophylaxis for the described procedures in Antrim Area Hospital.
Historical data of antimicrobial use were obtained from retrospective analysis of patients' charts, for those patients identified as having one of the following 'clean/contaminated' surgical procedures over the previous six months; cholecystectomy or abdominal hysterectomy. These data were analysed, and a protocol was introduced providing guidelines for the choice of antimicrobial agent, its administration time, route, dose, duration and frequency of treatment.
The main outcome measure was the success of the uptake of the protocol following its implementation.
There was a total of 285 patients identified, 105 prior to and 180 post implementation. Overall, 68% of patients received some form of prophylaxis in the first cycle, and 72% in the second.
Although the introduction of the protocol led to slight improvements in compliance with standard prescribing procedures, with an increase in single-dose prophylaxis, and a reduction in prolonged prophylactic treatment, the improvements did not reach expectations. This paper attempts to identify the possible barriers to protocol implementation.
本研究旨在为安特里姆地区医院上述手术的外科预防中抗菌药物的使用引入一种方案。
通过回顾性分析患者病历获取抗菌药物使用的历史数据，这些患者在过去六个月内被确定进行了以下“清洁/污染”手术之一：胆囊切除术或腹部子宫切除术。对这些数据进行分析，并引入了一个方案，为抗菌药物的选择、给药时间、途径、剂量、治疗持续时间和频率提供指导。
主要观察指标是该方案实施后的接受情况。
共确定285例患者，实施前105例，实施后180例。总体而言，68%的患者在第一个周期接受了某种形式的预防，第二个周期为72%。
尽管该方案的引入使标准处方程序的依从性略有提高，单剂量预防有所增加，长期预防性治疗有所减少，但改善未达预期。本文试图确定方案实施的可能障碍。
