Thjodleifsson B, Davídsdóttir K, Agnarsson U, Sigthórsson G, Kjeld M, Bjarnason I
Department of Medicine, University Hospital, Hringbraut, Reykjavík, Iceland.
Gut. 2002 Dec;51(6):816-7. doi: 10.1136/gut.51.6.816.
The safety of infant vaccination has been questioned in recent years. In particular it has been suggested that the measles, mumps, and rubella (MMR) vaccination leads to brain damage manifesting as autism consequent to the development of an "enterocolitis" in the immediate post-vaccination period.
To assess if MMR vaccination is associated with subclinical intestinal inflammation, which is central to the autistic "enterocolitis" theory.
We studied 109/58 infants, before and two and four weeks after immunisation with Pentavac and MMR vaccines, for the presence of intestinal inflammation (faecal calprotectin).
Neither vaccination was associated with any significant increase in faecal calprotectin concentrations.
The failure of the MMR vaccination to cause an intestinal inflammatory response provides evidence against the proposed gut-brain interaction that is central to the autistic "enterocolitis" hypothesis.
近年来，婴儿疫苗接种的安全性受到质疑。特别是有人提出，麻疹、腮腺炎和风疹（MMR）疫苗接种会导致脑损伤，表现为自闭症，这是由于接种疫苗后立即出现“小肠结肠炎”所致。
评估MMR疫苗接种是否与亚临床肠道炎症相关，这是自闭症“小肠结肠炎”理论的核心。
我们对109/58名婴儿在接种五联疫苗和MMR疫苗前、接种后两周和四周进行了研究，以检测肠道炎症（粪便钙卫蛋白）的存在情况。
两种疫苗接种均未导致粪便钙卫蛋白浓度显著升高。
MMR疫苗接种未能引起肠道炎症反应，这为反对自闭症“小肠结肠炎”假说核心的肠道与大脑相互作用理论提供了证据。
