Kobayashi Makoto, Kishimoto Nobuhito, Ohnishi Hisako, Tada Shinya, Ueda Nobuo, Kamei Tadashi, Fujita Jiro, Taguchi Hirokuni
3rd Department of Internal Medicine, Kochi Medical School, Okou-cho, Nankoku, Kochi 783-8505, Japan.
Nihon Kokyuki Gakkai Zasshi. 2002 Aug;40(8):637-43.
This study was designed to evaluate, in healthy volunteers, differences of bronchodilator responsiveness to a beta 2-agonist between those with the Arg 16/Gly 16 allele and those with the Gly 16/Gly 16 allele at codon 16 of beta 2 adrenoceptor polymorphism. Peak flow and pulmonary functions were measured by body plethysmography after the inhalation of procaterol. In the Arg 16/Gly 16 group, the resulting acute increase of V 25 and acute decrease of airway resistance were greater, and the bronchodilator effect of a single inhaled beta 2-agonist was longer, than those observed in the Gly 16/Gly 16 group. The present study showed that a single inhalation of procaterol has a varying bronchodilator effect on healthy adults, depending on the genotype of beta 2 adrenoceptor polymorphism at codon 16.
本研究旨在评估健康志愿者中，β2肾上腺素能受体基因多态性第16密码子处携带Arg 16/Gly 16等位基因者与携带Gly 16/Gly 16等位基因者对β2激动剂的支气管扩张反应差异。吸入丙卡特罗后，通过体容积描记法测量峰值流速和肺功能。与Gly 16/Gly 16组相比，Arg 16/Gly 16组吸入丙卡特罗后V 25的急性增加和气道阻力的急性降低更为显著，且单次吸入β2激动剂的支气管扩张作用持续时间更长。本研究表明，单次吸入丙卡特罗对健康成年人的支气管扩张作用存在差异，这取决于第16密码子处β2肾上腺素能受体基因多态性的基因型。
