Lae Marick E, Ahmed Iftikhar, Macon William R
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA.
Am J Clin Pathol. 2002 Nov;118(5):773-9. doi: 10.1309/N3GJ-N7A3-T98G-RYJL.
A recent study by Wellmann et al (Blood. 2000;96:398-404) detected clusterin expression in all 36 systemic anaplastic large cell lymphomas (ALCLs) tested, but not in any of 9 primary cutaneous ALCLs. Our purpose was to confirm the diagnostic usefulness of clusterin in systemic ALCL and to evaluate its efficacy in distinguishing primary cutaneous ALCL from secondary skin involvement by systemic ALCL. We examined clusterin expression by paraffin immunohistochemical analysis in 41 systemic ALCLs (18 ALK-1+ and 23 ALK-1-), 9 primary cutaneous ALCLs, and 4 secondary cutaneous ALCLs. Clusterin was positive in 95% of systemic ALCLs (39/41), including 100% (18/18) of the ALK-1+ cases and 91% (21/23) of the ALK-1- cases. Five (56%) of 9 primary and 3 (75%) of 4 secondary cutaneous ALCLs were positive for clusterin. Our observations confirm the diagnostic usefulness of clusterin in systemic ALCL, especially in the ALK-1- cases. However, our data fail to demonstrate its value in distinguishing primary from secondary cutaneous ALCL.
韦尔曼等人近期的一项研究（《血液》。2000年；96:398 - 404）在检测的所有36例系统性间变性大细胞淋巴瘤（ALCL）中均检测到簇集素表达，但在9例原发性皮肤ALCL中均未检测到。我们的目的是证实簇集素在系统性ALCL诊断中的有用性，并评估其在区分原发性皮肤ALCL与系统性ALCL继发性皮肤受累方面的效能。我们通过石蜡免疫组化分析检测了41例系统性ALCL（18例ALK - 1阳性和23例ALK - 1阴性）、9例原发性皮肤ALCL和4例继发性皮肤ALCL中的簇集素表达。簇集素在95%的系统性ALCL（39/41）中呈阳性，包括100%（18/18）的ALK - 1阳性病例和91%（21/23）的ALK - 1阴性病例。9例原发性皮肤ALCL中有5例（56%）和4例继发性皮肤ALCL中有3例（75%）簇集素呈阳性。我们的观察结果证实了簇集素在系统性ALCL诊断中的有用性，尤其是在ALK - 1阴性病例中。然而，我们的数据未能证明其在区分原发性与继发性皮肤ALCL方面的价值。
