Torlakovic Emina, Torlakovic Goran, Brunning Richard D
Department of Pathology, Norwegian Radium Hospital, Oslo.
Am J Clin Pathol. 2002 Nov;118(5):780-6. doi: 10.1309/EG2M-YHB9-WEFW-7H1R.
Five patterns of bone marrow infiltration by non-Hodgkin lymphoma or Hodgkin lymphoma are currently recognized, but a true follicular pattern of bone marrow involvement by follicular lymphoma has not been described. In 260 bone marrow trephine biopsy specimens involved by follicular lymphoma, we identified 12 cases with a follicular pattern of bone marrow involvement. The paratrabecular pattern was not present at all in 9, and it accounted for less than 10% of tumor burden in 3 cases. Malignant follicles in the bone marrow were similar to malignant follicles in the respective lymph nodes. Follicular dendritic cells were identified by immunohistochemical analysis. The true follicular pattern of bone marrow involvement by follicular lymphoma seems to be more frequent in women than in men. It is important to recognize this pattern of follicular lymphoma in the bone marrow because it is possible to misinterpret interstitial lymphoid aggregates as benign in the absence of the more characteristic paratrabecular pattern.
目前已认识到非霍奇金淋巴瘤或霍奇金淋巴瘤骨髓浸润的五种模式，但滤泡性淋巴瘤骨髓受累的真正滤泡模式尚未见描述。在260例滤泡性淋巴瘤累及的骨髓活检标本中，我们识别出12例具有骨髓受累滤泡模式的病例。9例完全不存在小梁旁模式，3例小梁旁模式占肿瘤负荷不到10%。骨髓中的恶性滤泡与相应淋巴结中的恶性滤泡相似。通过免疫组织化学分析鉴定出滤泡树突状细胞。滤泡性淋巴瘤骨髓受累的真正滤泡模式在女性中似乎比男性更常见。认识到骨髓中滤泡性淋巴瘤的这种模式很重要，因为在没有更具特征性的小梁旁模式时，可能会将间质淋巴样聚集物误判为良性。
