Kent Sara A, Variakojis Daina, Peterson LoAnn C
Department of Pathology, Northwestern University Medical School, Chicago, IL, USA.
Am J Clin Pathol. 2002 May;117(5):698-708. doi: 10.1309/MECJ-GLK1-WEBW-UEVE.
Few studies have characterized or compared the pathologic features of bone marrow involvement by extranodal (EMZL), splenic (SMZL), and nodal marginal zone lymphoma (NMZL). We evaluated 45 bone marrow biopsy specimens from 39 patients with marginal zone lymphomas. As previously reported, bone marrow involvement was frequent (100%) in patients with SMZL. We also identified lymphoma involving bone marrow in 11 (44%) of 25 patients with EMZL and 1 of 2 patients with NMZL. The patterns of infiltration were mixed in all groups; however, the extent of involvement was greater in SMZL than in EMZL. In addition, germinal centers were present in bone marrow biopsy specimens involved by lymphoma in 4 patients with SMZL. Intrasinusoidal infiltration was common (10/12 [83%]) and prominent in patients with bone marrow involvement by SMZL, but was not invariably present. Intrasinusoidal infiltration of the bone marrow also was not specific for SMZL since similar infiltrates, although subtle, also were found in patients with other small B-cell lymphoproliferative disorders, including 6 (55%) of 11 patients whose bone marrow samples were infiltrated by EMZL.
很少有研究对结外边缘区淋巴瘤（EMZL）、脾边缘区淋巴瘤（SMZL）和淋巴结边缘区淋巴瘤（NMZL）累及骨髓的病理特征进行描述或比较。我们评估了39例边缘区淋巴瘤患者的45份骨髓活检标本。如先前报道，SMZL患者骨髓受累很常见（100%）。我们还在25例EMZL患者中的11例（44%）以及2例NMZL患者中的1例中发现了累及骨髓的淋巴瘤。所有组的浸润模式都是混合性的；然而，SMZL的累及程度比EMZL更大。此外，4例SMZL患者的骨髓活检标本中，淋巴瘤累及的部位存在生发中心。窦内浸润很常见（12例中有10例[83%]），在骨髓受累的SMZL患者中尤为突出，但并非总是存在。骨髓的窦内浸润对SMZL也不具有特异性，因为在其他小B细胞淋巴增殖性疾病患者中也发现了类似的浸润，尽管很细微，包括11例骨髓样本被EMZL浸润的患者中的6例（55%）。
