• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

成年大鼠在行为学剂量的 Δ⁹-四氢大麻酚长期治疗后的骨髓增生

Myeloid hyperplasia in growing rats after chronic treatment with delta 9-THC at behavioral doses.

作者信息

Giusti G V, Carnevale A

出版信息

Arch Toxicol. 1975 Oct 20;34(2):169-72. doi: 10.1007/BF00353318.

DOI:10.1007/BF00353318
PMID:1242890
Abstract

Delta 9-THC at the dose of 1 mg/kg/die was administered subcutaneously in growing rats, from the second to the 30th day of life. A statistically significant myeloid hyperplasia was demonstrated, which persisted up to 4 months after the end of the treatment, together with significant blood granulocytosis.

摘要

在新生大鼠出生后第2天至第30天，以1毫克/千克/天的剂量皮下注射δ-9-四氢大麻酚。结果显示出具有统计学意义的髓细胞增生，这种增生在治疗结束后持续长达4个月，同时伴有明显的血液粒细胞增多。

相似文献

1
Myeloid hyperplasia in growing rats after chronic treatment with delta 9-THC at behavioral doses.成年大鼠在行为学剂量的 Δ⁹-四氢大麻酚长期治疗后的骨髓增生
Arch Toxicol. 1975 Oct 20;34(2):169-72. doi: 10.1007/BF00353318.
2
Effect of delta-THC on ethanol withdrawal in mice.δ-四氢大麻酚对小鼠乙醇戒断的影响。
Experientia. 1976 Jun 15;32(6):723-5. doi: 10.1007/BF01919854.
3
Repression of bone marrow leukopoiesis by delta9-tetrahydrocannabinol (delta9-THC).δ9-四氢大麻酚（δ9-THC）对骨髓白细胞生成的抑制作用
Res Commun Chem Pathol Pharmacol. 1974 Mar;7(3):613-6.
4
Reduction by 9-tetrahydrocannabinol in the blood pressure of hypertensive rats bearing regenerated adrenal glands.9-四氢大麻酚对再生肾上腺高血压大鼠血压的降低作用。
Br J Pharmacol. 1973 May;48(1):169-71. doi: 10.1111/j.1476-5381.1973.tb08236.x.
5
Effects of delta-9-THC and a water soluble ester of delta-9-THC on schedule-controlled behavior.
Pharmacol Biochem Behav. 1975 Jan-Feb;3(1):29-32. doi: 10.1016/0091-3057(75)90077-5.
6
The effect of cannabinoids on intestinal motility and their antinociceptive effect in mice.大麻素对小鼠肠道蠕动的影响及其镇痛作用。
Br J Pharmacol. 1973 Dec;49(4):588-94. doi: 10.1111/j.1476-5381.1973.tb08534.x.
7
Tolerance to the effect of delta1-tetrahydrocannabinol on corticosterone levels in mouse plasma produced by repeated administration of cannabis extract or delta1-tetrahydrocannabinol.通过重复给予大麻提取物或δ1-四氢大麻酚产生对δ1-四氢大麻酚对小鼠血浆皮质酮水平影响的耐受性。
Br J Pharmacol. 1974 Jul;51(3):391-7. doi: 10.1111/j.1476-5381.1974.tb10674.x.
8
Chronic delta-9-tetrahydrocannabinol. Transient and lasting effects on avoidance behavior.慢性 Δ9-四氢大麻酚。对回避行为的短暂和持久影响。
Pharmacol Biochem Behav. 1976 Jan;4(1):17-21. doi: 10.1016/0091-3057(76)90169-6.
9
Behavioral effects of prolonged administration of delta 9-tetrahydrocannabinol in the rat.
Psychopharmacology (Berl). 1983;80(4):325-30. doi: 10.1007/BF00432114.
10
Effects of long-term administration and withdrawal of tetrahydrocannabinols (delta 8-THC and delta 9-THC) on open-field behavior in rats.长期给予和停用四氢大麻酚（δ8-四氢大麻酚和δ9-四氢大麻酚）对大鼠旷场行为的影响。
Pharmacol Biochem Behav. 1973 May-Jun;1(3):243-9. doi: 10.1016/0091-3057(73)90111-1.

引用本文的文献

1
Muscular dystrophy in adult mice chronically treated with delta9-THC at behavioural doses.成年小鼠长期接受行为剂量的δ9-四氢大麻酚治疗后的肌肉萎缩症
Experientia. 1977 Feb 15;33(2):257-8. doi: 10.1007/BF02124097.
2
Decrease of serum alpha-tocopherol levels in rabbits after acute treatment with delta9-tetrahydrocannabinol.给予兔δ9-四氢大麻酚急性处理后血清α-生育酚水平降低。
Experientia. 1979 Jan 15;35(1):90-1. doi: 10.1007/BF01917896.

本文引用的文献

1
[Arteritis caused by Cannabis indica].[印度大麻引起的动脉炎]
Arch Mal Coeur Vaiss. 1960 Feb;53:143-7.
2
Forensic chemical study on marihuana. I. A detection method of the principal constituents by thin-layer and gas chromatographies.大麻的法医化学研究。I. 用薄层色谱法和气相色谱法检测主要成分的方法。
Chem Pharm Bull (Tokyo). 1968 May;16(5):822-6. doi: 10.1248/cpb.16.822.
3
Collapse after intravenous injection of hashish.静脉注射大麻后虚脱。
Br Med J. 1968 Jul 27;3(5612):229-30. doi: 10.1136/bmj.3.5612.229.
4
Effect of intravenous injection of marihuana.静脉注射大麻的效果。
JAMA. 1969 Oct 27;210(4):724-5.
5
Effects of a delta9-tetrahydrocannabinol (delta9-THC) metabolite on bone marrow myelopoiesis.δ9-四氢大麻酚（δ9-THC）代谢物对骨髓髓系造血的影响。
Res Commun Chem Pathol Pharmacol. 1974 Jun;8(2):393-6.
6
Acute, subacute and 23-day chronic marihuana inhalation toxicities in the rat.大鼠急性、亚急性和23天慢性吸入大麻的毒性
Toxicol Appl Pharmacol. 1974 Jun;28(3):428-41. doi: 10.1016/0041-008x(74)90228-2.
7
Repression of bone marrow leukopoiesis by delta9-tetrahydrocannabinol (delta9-THC).δ9-四氢大麻酚（δ9-THC）对骨髓白细胞生成的抑制作用
Res Commun Chem Pathol Pharmacol. 1974 Mar;7(3):613-6.
8
Tolerance to delta9-THC in adult rats with differential delta9-THC exposure when immature or during early adulthood.
Psychopharmacologia. 1974 Jan 14;34(3):181-90. doi: 10.1007/BF00421959.
9
[A simple technic for the quantitative determination of THC in hashish samples].[一种用于定量测定大麻脂样品中四氢大麻酚的简单技术]
Arch Kriminol. 1973 Sep-Oct;152(3):86-90.
10
[Effects on dogs of 3 months of inhalation of marijuana and tobacco smoke].[3个月吸入大麻烟雾和烟草烟雾对犬类的影响]
Union Med Can. 1974 Jan;103(1):65-71.