酪蛋白的各种磷酸肽对铁吸收的影响。

Influence of various phosphopeptides of caseins on iron absorption.

作者信息

Bouhallab Saíd, Cinga Vladas, Aít-Oukhatar Nabil, Bureau François, Neuville Dominique, Arhan Pierre, Maubois Jean-Louis, Bouglé Dominique

机构信息

Laboratoire de Recherches de Technologie Laitière, INRA, 65 rue de Saint Brieuc, F-35042 Rennes Cedex, France.

出版信息

J Agric Food Chem. 2002 Nov 20;50(24):7127-30. doi: 10.1021/jf025554v.

DOI:10.1021/jf025554v

PMID:12428971

Abstract

The influence of the origin and kind of caseinophosphopeptide (CPP) on iron absorption was assessed by comparing a commercially available CPP mixture (CPPs) and derived chromatographic fractions with the purified, chemically phosphopeptide of beta-casein [beta-CN(1-25)] using a perfused rat duodenal loop system; gluconate iron was used as control. Only iron complexed to beta-CN(1-25) displayed a better bioavailability than gluconate iron. The results obtained with various chromatographic fractions indicated that phosphopeptides of different origins (alpha(s)- versus beta-caseins) display specific effects. These findings contribute to the explanation of the discrepancy about the role of caseinophosphopeptides on mineral bioavailability in vivo.

摘要

通过使用灌注大鼠十二指肠袢系统，将市售酪蛋白磷酸肽混合物（CPPs）及其衍生的色谱分离组分与纯化的β-酪蛋白化学磷酸肽[β-CN(1-25)]进行比较，评估酪蛋白磷酸肽（CPP）的来源和种类对铁吸收的影响；以葡萄糖酸铁作为对照。只有与β-CN(1-25)络合的铁表现出比葡萄糖酸铁更好的生物利用度。用各种色谱分离组分获得的结果表明，不同来源的磷酸肽（αs-酪蛋白与β-酪蛋白）显示出特定的效应。这些发现有助于解释关于酪蛋白磷酸肽在体内矿物质生物利用度作用方面的差异。