Goto Hiroshi, Kousaka Akiko, Takano Shigeru, Usui Masahiko
Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan.
Am J Ophthalmol. 2002 Nov;134(5):773-5. doi: 10.1016/s0002-9394(02)01693-8.
To report a case of retinoblastoma that recurred 12 years after brachytherapy.
Interventional case report.
A 2-month-old boy presented in December 1983 with bilateral retinoblastoma and was treated with bilateral 198Au plaque radiotherapy, photocoagulation, and cryotherapy. He maintained a visual acuity of 20/200 in both eyes. In December 1995, he had a sudden decrease of vision in the right eye and vitreous hemorrhage with fluffy opacification.
In January 1996, cytopathologic examination of large keratic precipitates in the right eye demonstrated cells consistant with retinoblastoma. The right eye was enucleated and diffuse retinoblastoma was noted histopathologically. Systemic chemotherapy was given, and there has been no local recurrence or extraocular metastasis for 5 years.
This case emphasizes that long-term follow-up is essential for managing retinoblastoma after eye-preserving conservative therapy.
报告1例近距离放射治疗后12年复发的视网膜母细胞瘤病例。
介入性病例报告。
一名2个月大男孩于1983年12月因双侧视网膜母细胞瘤就诊，接受了双侧198Au敷贴放射治疗、光凝治疗和冷冻治疗。他双眼视力维持在20/200。1995年12月，他右眼视力突然下降，出现玻璃体积血并伴有絮状混浊。
1996年1月，对右眼大量角膜后沉着物进行细胞病理学检查，发现细胞与视网膜母细胞瘤一致。右眼行眼球摘除术，组织病理学检查发现弥漫性视网膜母细胞瘤。给予全身化疗，5年来无局部复发或眼外转移。
该病例强调，对于保留眼球的保守治疗后的视网膜母细胞瘤患者，长期随访至关重要。
