Daselaar Sander M, Veltman Dick J, Rombouts Serge A R B, Raaijmakers Jeroen G W, Lazeron Richard H C, Jonker Cees
Institute for Research in Extramural Medicine, Vrije Universiteit Medical Center, c/o Secr EMGO Dept vd Boechorstraat 7, 1081 BT Amsterdam, The Netherlands.
Behav Brain Res. 2002 Nov 15;136(2):399-404. doi: 10.1016/s0166-4328(02)00187-0.
In this study, we evaluated the use of a self-paced fMRI design, to allow a flexible speed of responding with only four alternating stimulus blocks to minimize the influence of task switching on a group of young subjects. This was done in view of our intention to use such a design on groups of elderly and demented subjects in the near future. In addition, the hypothesis was tested that the medial temporal lobe is involved in semantic memory similar to episodic memory using a semantic retrieval task. In line with previous imaging studies that compared a semantic (living/nonliving) to a perceptual (alphabetically ascending/descending) classification condition, activity was seen in lateral temporal and inferior frontal regions, indicating the applicability of our design. Additional activity was seen in the right, and, at a slightly lower threshold, also in the left MTL, providing support for the involvement of the MTL in retrieval from semantic memory.
在本研究中，我们评估了一种自定步速的功能磁共振成像（fMRI）设计的应用，该设计允许以灵活的反应速度，仅使用四个交替的刺激块，以尽量减少任务切换对一组年轻受试者的影响。这样做是鉴于我们打算在不久的将来将这种设计应用于老年和痴呆受试者群体。此外，我们还使用语义检索任务检验了内侧颞叶与情景记忆类似地参与语义记忆的假设。与之前将语义（生物/非生物）分类条件与知觉（按字母顺序升序/降序）分类条件进行比较的成像研究一致，在颞叶外侧和额下回区域观察到了活动，表明我们的设计具有适用性。在右侧观察到了额外的活动，在稍低的阈值下，左侧内侧颞叶也观察到了额外活动，这为内侧颞叶参与语义记忆检索提供了支持。
