Sudah O S, Coffin-Beach D, Muzzio F J
Department of Chemical and Biochemical Engineering, Rutgers University, PO Box 909 98, Brett Road, Piscataway, NJ 08855-0909, USA.
Int J Pharm. 2002 Oct 24;247(1-2):57-68. doi: 10.1016/s0378-5173(02)00377-0.
The roles of blender rotational speed and blender discharge on the homogeneity of free-flowing art sand and of a cohesive placebo formulation were investigated in the tote blender. For three practical operating speeds, 6, 10, and 14 RPM, spanning the entire range of commercial equipment, the homogeneity of the free-flowing mixture was independent of rotational speed and blender size. On the other hand, the homogeneity of the cohesive pharmaceutical powder mixture was dependent on vessel rotational speed in a complex fashion, with 10 RPM producing a better final mixture than either 5 or 15 RPM. The homogeneity of the free-flowing sand mixture was preserved when discharged into a vertical bin, while the homogeneity of the fine pharmaceutical powder mixture significantly improved after discharge from the tote blender.
在料斗式混合机中，研究了混合机转速和混合机卸料对自由流动艺术砂和粘性安慰剂制剂均匀性的影响。对于三种实际操作转速，即6、10和14转/分钟，涵盖了商业设备的整个转速范围，自由流动混合物的均匀性与转速和混合机尺寸无关。另一方面，粘性药物粉末混合物的均匀性以复杂的方式取决于容器转速，10转/分钟产生的最终混合物比5转/分钟或15转/分钟的更好。自由流动砂混合物卸料至垂直料仓时均匀性得以保持，而精细药物粉末混合物从料斗式混合机卸料后均匀性显著提高。
